血清甲基丙二酸水平升高与伴有蛋白尿的老年慢性肾脏病患者认知功能障碍的发生有关。
Increased serum methylmalonic acid levels were associated with the presence of cognitive dysfunction in older chronic kidney disease patients with albuminuria.
机构信息
Department of Nephrology, Xuanwu Hospital, Capital Medical University, Changchun Street 45#, 100053, Beijing, China.
National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.
出版信息
BMC Geriatr. 2024 Feb 15;24(1):159. doi: 10.1186/s12877-024-04759-y.
BACKGROUND
This study aimed to evaluate the correlation between serum methylmalonic acid (MMA) levels and cognition function in patients with chronic kidney disease (CKD).
METHODS
In this cross-sectional study, we included 537 CKD individuals aged ≥ 60-year-old with albuminuria from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Four cognitive tests including the Digit Symbol Substitution Test (DSST), the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Delayed Recall and Word Learning tests, and the Animal Fluency test (AF) were performed. Associations between MMA and cognition scores were assessed with linear regression models.
RESULTS
MMA level was negatively associated with residual renal function and nutrition status. After multivariate adjustment, elevated serum MMA levels were independently correlated with decline of cognition in CKD patients with albuminuria.
CONCLUSION
Our study showed that higher serum MMA levels were independently associated with the presence of cognition dysfunction in CKD patients. The exact pathogenesis of MMA and cognition needs further research.
背景
本研究旨在评估慢性肾脏病（CKD）患者血清甲基丙二酸（MMA）水平与认知功能之间的相关性。
方法
在这项横断面研究中，我们纳入了来自国家健康和营养检查调查（NHANES）2011-2014 年的 537 名年龄≥60 岁且有蛋白尿的 CKD 患者。进行了四项认知测试，包括数字符号替换测试（DSST）、阿尔茨海默病建立登记册联合会（CERAD）延迟回忆和单词学习测试以及动物流畅性测试（AF）。使用线性回归模型评估 MMA 与认知评分之间的相关性。
结果
MMA 水平与残余肾功能和营养状况呈负相关。经过多变量调整后，血清 MMA 水平升高与白蛋白尿的 CKD 患者认知功能下降独立相关。
结论
我们的研究表明，较高的血清 MMA 水平与 CKD 患者认知功能障碍的存在独立相关。MMA 和认知之间的确切发病机制需要进一步研究。
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