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The architecture of substrate-engaged TOM-TIM23 supercomplex reveals preprotein proximity sites for mitochondrial protein translocation.

作者信息

Wang Qiang, Zhuang Jinjin, Huang Rui, Guan Zeyuan, Yan Ling, Hong Sixing, Zhang Liying, Huang Can, Liu Zhu, Yin Ping

机构信息

National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.

出版信息

Cell Discov. 2024 Feb 16;10(1):19. doi: 10.1038/s41421-023-00643-y.

Abstract
摘要

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引用本文的文献

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Principles of cotranslational mitochondrial protein import.
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本文引用的文献

1
Molecular pathway of mitochondrial preprotein import through the TOM-TIM23 supercomplex.
Nat Struct Mol Biol. 2023 Dec;30(12):1996-2008. doi: 10.1038/s41594-023-01103-7. Epub 2023 Sep 11.
2
Structural basis of mitochondrial protein import by the TIM23 complex.
Nature. 2023 Sep;621(7979):620-626. doi: 10.1038/s41586-023-06239-6. Epub 2023 Jun 21.
3
Mitochondrial protein transport: Versatility of translocases and mechanisms.
Mol Cell. 2023 Mar 16;83(6):890-910. doi: 10.1016/j.molcel.2023.02.020.
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Role of the TOM Complex in Protein Import into Mitochondria: Structural Views.
Annu Rev Biochem. 2022 Jun 21;91:679-703. doi: 10.1146/annurev-biochem-032620-104527. Epub 2022 Mar 14.
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Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.
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Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution.
Nat Struct Mol Biol. 2019 Dec;26(12):1158-1166. doi: 10.1038/s41594-019-0339-2. Epub 2019 Nov 18.
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Structure of the mitochondrial import gate reveals distinct preprotein paths.
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Mitochondrial proteins: from biogenesis to functional networks.
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Mitochondrial Machineries for Protein Import and Assembly.
Annu Rev Biochem. 2017 Jun 20;86:685-714. doi: 10.1146/annurev-biochem-060815-014352. Epub 2017 Mar 15.
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Molecular architecture of the active mitochondrial protein gate.
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