Lee T H, Choi K C, Park Y K, Choi J K
Diabetes Res Clin Pract. 1985 Oct;1(3):155-9. doi: 10.1016/s0168-8227(85)80005-x.
The effect of Vacor diabetes mellitus on the quadriceps muscle capillary basement membrane thickness has been examined by the electron microscopic method. With this procedure, it was possible to obtain an objective evaluation of the significance of capillary basement membrane thickening in Vacor diabetes mellitus. The results of such a study on the muscle capillary basement membrane in 10 normal subjects and 9 Vacor-poisoned patients have demonstrated the following: (1) the average basement membrane width of Vacor patients (2801 A +/- SD 614) is over twice that of normal subjects (1300 +/- 185 A), and all 9 cases demonstrated muscle capillary basement membrane thickening; (2) there is a significant association of basement membrane width with age (P less than 0.01), but not with the duration of the disease or fasting blood glucose values in the Vacor group. The results of the present study indicate that diabetes mellitus induced by Vacor poisoning can lead to microangiopathy, and that such basement membrane thickening is an early and consistent finding.
已采用电子显微镜方法研究了灭鼠灵糖尿病对股四头肌毛细血管基底膜厚度的影响。通过该程序，可以对灭鼠灵糖尿病中毛细血管基底膜增厚的意义进行客观评估。对10名正常受试者和9名灭鼠灵中毒患者的肌肉毛细血管基底膜进行此类研究的结果表明：（1）灭鼠灵患者的平均基底膜宽度（2801埃±标准差614）是正常受试者（1300±185埃）的两倍多，且所有9例均表现出肌肉毛细血管基底膜增厚；（2）基底膜宽度与年龄有显著相关性（P小于0.01），但与灭鼠灵组的病程或空腹血糖值无关。本研究结果表明，灭鼠灵中毒诱发的糖尿病可导致微血管病变，且这种基底膜增厚是一个早期且一致的发现。
