Salazar H, Chez R A, Pardo M
Am J Pathol. 1973 Jun;71(3):437-46.
The effects of streptozotocin-induced carbohydrate intolerance on the basement membrane of muscle capillaries were studied in 5 adult rhesus monkeys. Biopsies were obtained 6 to 15 months after administration of the drug. Although wide variations in the thickness of basement membranes were observed between capillaries in the same biopsy of each animal, no significant differences were found between the mean values of the experimental group when compared with those of 5 control animals. These results seem to support the "genetic theory" of diabetic microangiopathies. It may prove of considerable interest to repeat these observations in more chronic stages of carbohydrate intolerance.
在5只成年恒河猴中研究了链脲佐菌素诱导的碳水化合物不耐受对肌肉毛细血管基底膜的影响。在给药后6至15个月获取活检样本。尽管在每只动物的同一次活检中,毛细血管之间观察到基底膜厚度存在很大差异,但与5只对照动物相比,实验组的平均值没有发现显著差异。这些结果似乎支持糖尿病微血管病变的“遗传理论”。在碳水化合物不耐受的更慢性阶段重复这些观察结果可能会有相当大的意义。