Established latent herpes simplex virus infections of mice not affected by adenosine monophosphate treatment.

Hairless mice with established latent herpes simplex virus infections in their trigeminal ganglia were treated for different time intervals with various doses of adenosine monophosphate. The treatment did not eliminate the latent infection and the results suggest that the drug did not reduce the amount of reactivatable virus present in latently infected ganglia. It appears therefore that adenosine monophosphate exerts its antiviral effects through non-specific mechanisms.