Ernst J, Sy E, Lorian V, Kim Y
Drugs Exp Clin Res. 1985;11(6):357-60.
A patient with a pleural effusion containing Staphylococcus aureus was treated with nafcillin. Another patient with bilateral upper lobe infiltrates which grew S. aureus from a catheter inserted through a fiberoptic bronchoscope into the lesion was also treated with nafcillin. Electron microscopy of organisms grown while the patients were receiving nafcillin showed staphylococci which were twice as large as normal and contained multiple cross-walls and normal peripheral cell walls. Such abnormal staphylococci result from exposure to subminimum inhibitory concentrations of beta-lactam antibiotics.
一名胸腔积液中含有金黄色葡萄球菌的患者接受了萘夫西林治疗。另一名双侧上叶浸润患者，通过纤维支气管镜插入病变处的导管培养出金黄色葡萄球菌，该患者也接受了萘夫西林治疗。在患者接受萘夫西林治疗期间对培养出的细菌进行电子显微镜检查，结果显示葡萄球菌的大小是正常葡萄球菌的两倍，含有多个横壁和正常的外周细胞壁。这种异常葡萄球菌是由于暴露于低于最低抑菌浓度的β-内酰胺类抗生素所致。
