肝移植受者呼出气一氧化氮分数高于一般人群对照：一项队列研究。

Fraction of exhaled nitric oxide is higher in liver transplant recipients than in controls from the general population: a cohort study.

机构信息

Department of Infectious Diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Department of Gastroenterology, Odense University Hospital, Odense, Denmark.

出版信息

Front Immunol. 2024 Feb 1;15:1330923. doi: 10.3389/fimmu.2024.1330923. eCollection 2024.

DOI:10.3389/fimmu.2024.1330923

PMID:38361926

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10867152/

Abstract

BACKGROUND

Fraction of exhaled nitric oxide with an expiratory flow of 50 mL/s (FNO) is a biomarker of eosinophilic airway inflammation. Liver transplant recipients have an increased risk of pulmonary infections, but little is known about the burden of chronic pulmonary diseases in this group. We aimed to assess the prevalence of elevated FNO in liver transplant recipients and compare it to controls from the general population.

METHODS

FNO was measured in 271 liver transplant recipients from The Danish Comorbidity in Liver Transplant Recipients (DACOLT) study and 1,018 age- and sex-matched controls from The Copenhagen General Population Study (CGPS). Elevated FNO was defined as ≥25 or ≥50 parts per billion (ppb). The analyses were adjusted for known and suspected confounders.

RESULTS

The median age of the liver transplant recipients was 55 years (interquartile range (IQR) 46-64), and 58% were men. The liver transplant recipients had a higher median FNO than the controls [16 ppb (IQR 10-26) vs. 13 ppb (IQR 8-18.), < 0.001]. Furthermore, the liver transplant recipients had a higher prevalence of elevated FNO (for FNO ≥25 ppb 27% vs. 11%, < 0.001 and ≥50 ppb 4% vs. 2%, = 0.02). The results were similar after adjusting for age, sex, smoking status, use of airway medication, and blood eosinophil counts [the adjusted odds ratio (OR) for FNO ≥25 ppb was 3.58 (95% CI: 2.50-5.15, < 0.0001) and the adjusted OR for FNO ≥50 ppb was 3.14 (95% CI: 1.37-7.20, = 0.007)].

CONCLUSION

The liver transplant recipients had elevated FNO, implying increased eosinophilic airway inflammation. The clinical impact of this finding needs further investigation.

摘要

背景

呼气中 50ml/s 流速的一氧化氮分数（FENO）是气道嗜酸性粒细胞炎症的生物标志物。肝移植受者发生肺部感染的风险增加，但对于该人群中慢性肺部疾病的负担知之甚少。我们旨在评估肝移植受者中升高的 FENO 的患病率，并将其与来自一般人群的对照组进行比较。

方法

在丹麦肝移植受者合并症（DACOLT）研究中，测量了 271 例肝移植受者的 FENO，在哥本哈根普通人群研究（CGPS）中，测量了 1018 例年龄和性别匹配的对照组的 FENO。升高的 FENO 定义为≥25 或≥50 皮克/十亿（ppb）。分析调整了已知和可疑的混杂因素。

结果

肝移植受者的中位年龄为 55 岁（四分位距（IQR）46-64），58%为男性。与对照组相比，肝移植受者的中位 FENO 更高[16 ppb（IQR 10-26）vs. 13 ppb（IQR 8-18），<0.001]。此外，肝移植受者升高的 FENO 患病率更高（FENO≥25 ppb 为 27% vs. 11%，<0.001；FENO≥50 ppb 为 4% vs. 2%，=0.02）。调整年龄、性别、吸烟状况、气道药物使用和血嗜酸性粒细胞计数后，结果相似[FENO≥25 ppb 的调整比值比（OR）为 3.58（95%CI：2.50-5.15，<0.0001）；FENO≥50 ppb 的调整 OR 为 3.14（95%CI：1.37-7.20，=0.007）]。