State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Guangzhou Laboratory, Bio-island, Guangzhou, China.
J Transl Med. 2021 Dec 7;19(1):496. doi: 10.1186/s12967-021-03159-9.
Pulmonary fibrosis is the end stage of a broad range of heterogeneous interstitial lung diseases and more than 200 factors contribute to it. In recent years, the relationship between virus infection and pulmonary fibrosis is getting more and more attention, especially after the outbreak of SARS-CoV-2 in 2019, however, the mechanisms underlying the virus-induced pulmonary fibrosis are not fully understood. Here, we review the relationship between pulmonary fibrosis and several viruses such as Human T-cell leukemia virus (HTLV), Human immunodeficiency virus (HIV), Cytomegalovirus (CMV), Epstein-Barr virus (EBV), Murine γ-herpesvirus 68 (MHV-68), Influenza virus, Avian influenza virus, Middle East Respiratory Syndrome (MERS)-CoV, Severe acute respiratory syndrome (SARS)-CoV and SARS-CoV-2 as well as the mechanisms underlying the virus infection induced pulmonary fibrosis. This may shed new light on the potential targets for anti-fibrotic therapy to treat pulmonary fibrosis induced by viruses including SARS-CoV-2.
肺纤维化是广泛异质性间质性肺疾病的终末期，有 200 多种因素与之相关。近年来，病毒感染与肺纤维化之间的关系越来越受到关注，特别是 2019 年 SARS-CoV-2 爆发后。然而，病毒引起肺纤维化的机制尚不完全清楚。在这里，我们综述了肺纤维化与几种病毒（如人类 T 细胞白血病病毒（HTLV）、人类免疫缺陷病毒（HIV）、巨细胞病毒（CMV）、爱泼斯坦-巴尔病毒（EBV）、鼠γ疱疹病毒 68（MHV-68）、流感病毒、禽流感病毒、中东呼吸综合征（MERS）-CoV、严重急性呼吸综合征（SARS）-CoV 和 SARS-CoV-2）之间的关系，以及病毒感染诱导肺纤维化的机制。这可能为包括 SARS-CoV-2 在内的病毒引起的肺纤维化的抗纤维化治疗提供新的潜在靶点。
