Georges Gabriel, Trudeau François, Potvin Jeannot, Potus François, Martineau Sandra, Généreux Philippe
Quebec Heart and Lung Institute, Quebec, Quebec, Canada.
Puzzle Medical Devices Inc., Montreal, Quebec, Canada.
JACC Basic Transl Sci. 2023 Oct 4;9(1):33-42. doi: 10.1016/j.jacbts.2023.07.005. eCollection 2024 Jan.
von Willebrand Factor (VWF) destruction is common with current heart pumps. This study evaluates VWF activity with ModulHeart, a novel device using 3 micropumps in parallel. In model 1, ModulHeart was compared with Impella devices in vitro. In model 2, 3 healthy swine received ModulHeart. Model 3 includes VWF data from patients who underwent protected percutaneous coronary intervention with ModulHeart. In models 1, 2, and 3, ModulHeart resulted in preservation of VWF, whereas there was a 27% and 19% reduction in VWF activity with the Impella CP and 5.0, respectively. ModulHeart features a unique design and demonstrated preservation of VWF activity.
血管性血友病因子（VWF）的破坏在当前的心脏泵中很常见。本研究使用ModulHeart评估VWF活性，ModulHeart是一种新型设备，采用3个并联的微型泵。在模型1中，将ModulHeart与体外的Impella设备进行比较。在模型2中，3只健康猪接受了ModulHeart。模型3包括接受ModulHeart进行保护性经皮冠状动脉介入治疗的患者的VWF数据。在模型1、2和3中，ModulHeart可使VWF得以保留，而Impella CP和Impella 5.0的VWF活性分别降低了27%和19%。ModulHeart具有独特的设计，并证明可保留VWF活性。
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