一例因肾性低尿酸血症导致的心动过速性急性肾损伤病例。
A case of tachycardia-induced acute kidney injury by renal hypouricemia.
作者信息
Izumi Gaku, Takeda Atsuhito, Okamoto Takayuki, Shida Satoru, Matsuo Hirotaka
机构信息
Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Department of Pediatrics, Ebetsu City Hospital, Ebetsu, Japan.
出版信息
J Cardiol Cases. 2023 Nov 10;29(2):59-62. doi: 10.1016/j.jccase.2023.10.009. eCollection 2024 Feb.
UNLABELLED
Idiopathic renal hypouricemia is an autosomal recessive hereditary disease, characterized by hypouricemia and high renal fractional excretion of uric acid, and can be complicated by acute kidney injury after anaerobic exercise. However, no report has suggested tachycardia-induced acute kidney injury complicated with renal hypouricemia. We herein report the case of a 12-year-old female with tachycardia-induced acute kidney injury complicated with renal hypouricemia. It is an important issue that the tachycardias and acute kidney injury due to renal hypouricemia can be deteriorating factors for each other through the reactive oxygen species.
LEARNING OBJECTIVE
Renal hypouricemia is rare, with a frequency of 0.2-0.4 %, but is often overlooked and can produce acute kidney injury after exercise. Tachyarrhythmia can be an inducer of acute kidney injury in patients with renal hypouricemia.
未标注
特发性肾性低尿酸血症是一种常染色体隐性遗传性疾病，其特征为低尿酸血症和尿酸肾排泄分数升高，无氧运动后可并发急性肾损伤。然而，尚无报告提示心动过速诱发的急性肾损伤合并肾性低尿酸血症。我们在此报告一例12岁女性，患有心动过速诱发的急性肾损伤并合并肾性低尿酸血症。肾性低尿酸血症所致的心动过速和急性肾损伤可通过活性氧相互成为恶化因素，这是一个重要问题。
学习目标
肾性低尿酸血症罕见，发病率为0.2 - 0.4%，但常被忽视，运动后可导致急性肾损伤。快速性心律失常可能是肾性低尿酸血症患者急性肾损伤的诱发因素。
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