Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Jiangsu Province, Nanjing, People's Republic of China.
Department of Anesthesiology, Affiliated Zhongda Hospital of Southeast University, Jiangsu Province, Nanjing, People's Republic of China.
Mol Neurobiol. 2024 Sep;61(9):7075-7091. doi: 10.1007/s12035-024-04045-3. Epub 2024 Feb 17.
The development of central nervous system (CNS) can form perceptual, memory, and cognitive functions, while injuries to CNS often lead to severe neurological dysfunction and even death. As one of the prevalent post-translational modifications (PTMs), O-GlcNAcylation has recently attracted great attentions due to its functions in regulating the activity, subcellular localization, and stability of target proteins. It has been indicated that O-GlcNAcylation could interact with phosphorylation, ubiquitination, and methylation to jointly regulate the function and activity of proteins. Furthermore, a growing number of studies have suggested that O-GlcNAcylation played an important role in the CNS. During development, O-GlcNAcylation participated in the neurogenesis, neuronal development, and neuronal function. In addition, O-GlcNAcylation was involved in the progress of CNS injuries including ischemic stroke, subarachnoid hemorrhage (SAH), and intracerebral hemorrhage (ICH) and played a crucial role in the improvement of brain damage such as attenuating cognitive impairment, inhibiting neuroinflammation, suppressing endoplasmic reticulum (ER) stress, and maintaining blood-brain barrier (BBB) integrity. Therefore, O-GlcNAcylation showed great promise as a potential target in CNS development and injuries. In this article, we presented a review highlighting the role of O-GlcNAcylation in CNS development and injuries. Hence, on the basis of these properties and effects, intervention with O-GlcNAcylation may be developed as therapeutic agents for CNS diseases.
中枢神经系统（CNS）的发育可以形成感知、记忆和认知功能，而 CNS 的损伤通常会导致严重的神经功能障碍甚至死亡。作为一种普遍的翻译后修饰（PTM）之一，O-GlcNAcylation 由于其调节靶蛋白活性、亚细胞定位和稳定性的功能而最近引起了极大的关注。已经表明，O-GlcNAcylation 可以与磷酸化、泛素化和甲基化相互作用，共同调节蛋白质的功能和活性。此外，越来越多的研究表明 O-GlcNAcylation 在中枢神经系统中起着重要作用。在发育过程中，O-GlcNAcylation 参与神经发生、神经元发育和神经元功能。此外，O-GlcNAcylation 参与包括缺血性中风、蛛网膜下腔出血（SAH）和脑出血（ICH）在内的中枢神经系统损伤的进展，并在改善脑损伤方面发挥着至关重要的作用，例如减轻认知障碍、抑制神经炎症、抑制内质网（ER）应激和维持血脑屏障（BBB）完整性。因此，O-GlcNAcylation 作为中枢神经系统发育和损伤的潜在靶点具有很大的应用前景。本文综述了 O-GlcNAcylation 在中枢神经系统发育和损伤中的作用。因此，基于这些特性和作用，干预 O-GlcNAcylation 可能被开发为中枢神经系统疾病的治疗药物。
