Zhang Junli, Xu Zhenghui, Fu Yu, Chen Lu
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Department of Clinical Nutrition, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Endocrine. 2024 Jul;85(1):196-205. doi: 10.1007/s12020-024-03689-4. Epub 2024 Feb 17.
Diabetic peripheral neuropathy (DPN), the very prevalent microvascular complication of type 2 diabetes mellitus (T2DM), severely threatens the quality of life of diabetic patients. Thus, prevention of DPN is extremely important for public health, and the identification of potential biomarkers may help with early prevention. Our work determined the association between phase angles (PhAs) and the risk of DPN in T2DM patients.
This cross-sectional study recruited 697 T2DM patients from the Third Affiliated Hospital of Soochow University. All patients were divided into the non-diabetic peripheral neuropathy group and diabetic peripheral neuropathy group, and the DPN group was further divided into low, medium, and high diabetic foot ulcer risk groups according to vibration perception threshold results. Using univariate and multivariate logistic regression analyses continuously, the relationship between PhAs (arms, legs, trunk, and whole body) and the risk of DPN were evaluated. Further analysis was conducted on different subgroups of the study population.
After adjusting for the potential covariates, multivariate logistic regression analyses indicated that PhAs of the arms, legs, and whole body correlated inversely with the risk of DPN. However, the PhA of the trunk had no significant correlation with DPN. According to the stratified subgroup analysis, the negative association between PhA of the whole body and the risk of DPN remained significant in the sex and BMI group except for participants with BMI ≥ 28 kg/m².
For the first time, PhAs were acknowledged to be independently associated with DPN. Further exploration is needed to explain the findings.
糖尿病周围神经病变（DPN）是2型糖尿病（T2DM）非常常见的微血管并发症，严重威胁糖尿病患者的生活质量。因此，预防DPN对公众健康极为重要，识别潜在的生物标志物可能有助于早期预防。我们的研究确定了相位角（PhAs）与T2DM患者发生DPN风险之间的关联。
这项横断面研究招募了苏州大学附属第三医院的697例T2DM患者。所有患者被分为非糖尿病周围神经病变组和糖尿病周围神经病变组，DPN组根据振动觉阈值结果进一步分为糖尿病足溃疡低、中、高风险组。连续使用单因素和多因素逻辑回归分析，评估PhAs（手臂、腿部、躯干和全身）与DPN风险之间的关系。对研究人群的不同亚组进行了进一步分析。
在调整潜在协变量后，多因素逻辑回归分析表明，手臂、腿部和全身的PhAs与DPN风险呈负相关。然而，躯干的PhA与DPN无显著相关性。根据分层亚组分析，除BMI≥28 kg/m²的参与者外，全身PhA与DPN风险之间的负相关在性别和BMI组中仍然显著。
首次确认PhAs与DPN独立相关。需要进一步探索以解释这些发现。
