Soler Climent E, Lledó Rico L, García Poblet M, Sospedra I, Junquera-Godoy I, Martinez-De-Juan J L, Gomis-Tena J, Saiz J, Prats-Boluda G, Santoyo Pérez R
Research and Innovation Area. Health Department Elche General Hospital, Elche, Alicante, Spain.
FISABIO, Valencia, Spain.
Metabol Open. 2024 Aug 30;23:100315. doi: 10.1016/j.metop.2024.100315. eCollection 2024 Sep.
Approximately 25 % of diabetic patients develop diabetic foot ulcers (DFUs), significantly increasing morbidity, mortality, and healthcare costs. Effective control and prevention are crucial.
This study aims to identify easily measurable parameters for predicting DFU risk by assessing the correlation between Phase Angle (PA) and the Triglyceride-Glucose (TyG) index with DFU risk.
A comparative case-control study was conducted at the General Hospital of Elche from March to June 2023 with 70 participants (33 with diabetes, 37 without). Cases had diabetes for over five years and a diabetic foot risk grade of 0, 1, or 2 (IWGDF 2019). Exclusion criteria included inability to walk, prior use of orthoses, and severe complications like edema or wounds. Predictive variables were PA, TyG index, body composition, and biochemical markers. Statistical analyses included Pearson/Spearman tests for correlations, Student's t-test/Mann-Whitney test for group comparisons, and ANOVA/Kruskal-Wallis tests for normally and non-normally distributed variables.
PAand TyG index were strongly linked to diabetic foot risk, supporting their potential as biomarkers. Significant relationships with other relevant biomarkers were also confirmed.
PA and TyG index are valuable, easily measurable biomarkers for assessing diabetic foot risk, and can be monitored in primary care settings. Implementing these biomarkers in routine practice could enhance the management of diabetic complications, particularly in resource-limited settings, by enabling early detection and intervention, thus improving patient outcomes and reducing the burden of advanced complications.
约25%的糖尿病患者会发生糖尿病足溃疡（DFU），这显著增加了发病率、死亡率和医疗成本。有效控制和预防至关重要。
本研究旨在通过评估相角（PA）和甘油三酯-葡萄糖（TyG）指数与DFU风险之间的相关性，确定易于测量的预测DFU风险的参数。
2023年3月至6月在埃尔切总医院进行了一项病例对照研究，共有70名参与者（33名糖尿病患者，37名非糖尿病患者）。病例组患者患有糖尿病超过五年，糖尿病足风险等级为0、1或2（国际糖尿病足工作组，2019年）。排除标准包括无法行走、既往使用矫形器以及存在水肿或伤口等严重并发症。预测变量包括PA、TyG指数、身体成分和生化标志物。统计分析包括用于相关性分析的Pearson/Spearman检验、用于组间比较的Student t检验/Mann-Whitney检验以及用于正态和非正态分布变量的ANOVA/Kruskal-Wallis检验。
PA和TyG指数与糖尿病足风险密切相关，支持它们作为生物标志物的潜力。还证实了它们与其他相关生物标志物的显著关系。
PA和TyG指数是评估糖尿病足风险的有价值且易于测量的生物标志物，可在初级保健环境中进行监测。在常规实践中应用这些生物标志物可以通过早期检测和干预加强糖尿病并发症的管理，特别是在资源有限的环境中，从而改善患者预后并减轻晚期并发症的负担。
