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Achalasia-associated megaoesophagus presenting with dyspnoea and cough.贲门失弛缓症相关巨大食管伴呼吸困难和咳嗽。
BMJ Case Rep. 2024 Feb 17;17(2):e258950. doi: 10.1136/bcr-2023-258950.
2
Circumferential Heller myotomy can relieve chest pain in patients with achalasia: a prospective clinical trial.贲门失弛缓症患者行贲门周围肌层切开术可缓解胸痛:一项前瞻性临床试验
Esophagus. 2020 Oct;17(4):468-476. doi: 10.1007/s10388-020-00738-5. Epub 2020 Apr 4.
3
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[Heller laparoscopic cardiomyotomy with Douro fundoplication - a standard for the treatment of cardiac achalasia in children].[采用杜罗胃底折叠术的海勒腹腔镜贲门肌切开术——儿童贲门失弛缓症治疗的标准]
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J Laparoendosc Adv Surg Tech A. 2016 Sep;26(9):675-9. doi: 10.1089/lap.2016.0246. Epub 2016 Jun 10.
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Laparoscopic Heller myotomy and Dor fundoplication for esophageal achalasia in children.腹腔镜下Heller肌切开术联合Dor胃底折叠术治疗儿童贲门失弛缓症
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Laparoscopic Heller myotomy and Dor fundoplication for achalasia: analysis of successes and failures.腹腔镜下Heller肌切开术联合Dor胃底折叠术治疗贲门失弛缓症:成功与失败分析
Arch Surg. 2001 Aug;136(8):870-7. doi: 10.1001/archsurg.136.8.870.
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Achalasia-Specific Quality of Life After Pneumatic Dilation or Laparoscopic Heller Myotomy With Partial Fundoplication: A Multicenter, Randomized Clinical Trial.气囊扩张术或腹腔镜下贲门肌切开术加部分胃底折叠术后贲门失弛缓症患者的特定生活质量:一项多中心随机临床试验
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Sudden-Onset Back Pain and Intermittent Dyspnea While Eating: A Case of Pediatric Achalasia.进食时突发背痛和间歇性呼吸困难:一例小儿贲门失弛缓症病例
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本文引用的文献

1
Robotic Heller myotomy and Dor fundoplication: Twelve steps.机器人辅助Heller肌切开术和Dor胃底折叠术:十二个步骤。
JTCVS Tech. 2022 Aug 20;16:163-168. doi: 10.1016/j.xjtc.2022.07.028. eCollection 2022 Dec.
2
Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0.高分辨率食管动力障碍:芝加哥分类版本 4.0。
Neurogastroenterol Motil. 2021 Jan;33(1):e14058. doi: 10.1111/nmo.14058.
3
ASGE guideline on the management of achalasia.ASGE 关于贲门失弛缓症治疗的指南。
Gastrointest Endosc. 2020 Feb;91(2):213-227.e6. doi: 10.1016/j.gie.2019.04.231. Epub 2019 Dec 13.
4
Endoscopic or Surgical Myotomy in Patients with Idiopathic Achalasia.特发性贲门失弛缓症患者的内镜或手术肌切开术。
N Engl J Med. 2019 Dec 5;381(23):2219-2229. doi: 10.1056/NEJMoa1905380.
5
Effect of Peroral Endoscopic Myotomy vs Pneumatic Dilation on Symptom Severity and Treatment Outcomes Among Treatment-Naive Patients With Achalasia: A Randomized Clinical Trial.经口内镜肌切开术与气囊扩张治疗原发性贲门失弛缓症患者的疗效比较:一项随机临床试验。
JAMA. 2019 Jul 9;322(2):134-144. doi: 10.1001/jama.2019.8859.
6
Robotic versus laparoscopic approach to treat symptomatic achalasia: systematic review with meta-analysis.机器人与腹腔镜治疗症状性贲门失弛缓症的比较:系统评价与荟萃分析。
Dis Esophagus. 2019 Dec 13;32(10):1-8. doi: 10.1093/dote/doz062.
7
Incidence, morbidity and mortality of patients with achalasia in England: findings from a study of nationwide hospital and primary care data.英格兰贲门失弛缓症患者的发病率、患病率和死亡率:一项基于全国医院和初级保健数据的研究结果。
Gut. 2019 May;68(5):790-795. doi: 10.1136/gutjnl-2018-316089. Epub 2018 Jun 20.
8
Long-term results of the European achalasia trial: a multicentre randomised controlled trial comparing pneumatic dilation versus laparoscopic Heller myotomy.欧洲贲门失弛缓症试验的长期结果:一项比较气囊扩张与腹腔镜 Heller 肌切开术的多中心随机对照试验。
Gut. 2016 May;65(5):732-9. doi: 10.1136/gutjnl-2015-310602. Epub 2015 Nov 27.
9
Achalasia with megaesophagus and tracheal compression in a young patient: A case report.一名年轻患者的贲门失弛缓症合并巨食管及气管受压:病例报告
Int J Surg Case Rep. 2015;14:16-8. doi: 10.1016/j.ijscr.2015.06.020. Epub 2015 Jun 26.
10
Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia.位于 HLA-DQ 区域的常见变异与特发性贲门失弛缓症的易感性相关。
Nat Genet. 2014 Aug;46(8):901-4. doi: 10.1038/ng.3029. Epub 2014 Jul 6.

贲门失弛缓症相关巨大食管伴呼吸困难和咳嗽。

Achalasia-associated megaoesophagus presenting with dyspnoea and cough.

机构信息

Department of Upper Gastrointestinal Surgery, Hull University Teaching Hospitals NHS Trust, Cottingham, UK

Department of Upper Gastrointestinal Surgery, Hull University Teaching Hospitals NHS Trust, Cottingham, UK.

出版信息

BMJ Case Rep. 2024 Feb 17;17(2):e258950. doi: 10.1136/bcr-2023-258950.

DOI:10.1136/bcr-2023-258950
PMID:38367990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10875499/
Abstract

We present an unusual case of achalasia presenting with dyspnoea and persistent cough. These symptoms persisted for months, leading to the patient undergoing a chest X-ray by her general practitioner which showed right basal consolidation and a density extending along the right mediastinum. CT scan was done which revealed megaoesophagus with a diameter of 7 cm causing tracheal compression, as well as right basal consolidation, consistent with aspiration. Further history revealed 6-month history of progressive swallowing difficulty, retrosternal chest pain and shortness of breath which worsened when eating solid foods. After thorough workup, a diagnosis of idiopathic achalasia (type II) was made. She was treated with laparoscopic Heller cardiomyotomy and Dor fundoplication with significant improvement at follow-up. Dyspnoea and respiratory symptoms are unusual presenting symptoms, suggesting a need to consider achalasia in a wider range of presentations. Successful treatment of achalasia depends on timely diagnosis and intervention prior to oesophageal failure.

摘要

我们呈现了一例以呼吸困难和持续性咳嗽为表现的不典型贲门失弛缓症。这些症状持续了数月,导致患者接受了全科医生的胸部 X 光检查,显示右侧基底实变和密度沿右侧纵隔延伸。进行了 CT 扫描,显示巨食管直径为 7 厘米,导致气管受压,以及右侧基底实变,符合吸入性肺炎。进一步的病史显示,患者有 6 个月的进行性吞咽困难、胸骨后胸痛和呼吸困难的病史,进食固体食物时症状加重。经过全面检查,诊断为特发性贲门失弛缓症(II 型)。她接受了腹腔镜 Heller 肌切开术和 Dor 胃底折叠术治疗,随访时症状明显改善。呼吸困难和呼吸症状是不常见的表现症状,提示需要在更广泛的表现中考虑贲门失弛缓症。成功治疗贲门失弛缓症取决于在食管衰竭之前及时诊断和干预。