Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, Mexico.
Doctorado en Ciencias Biológicas y de La Salud, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, Mexico.
Trop Anim Health Prod. 2024 Feb 17;56(2):81. doi: 10.1007/s11250-024-03926-y.
The use of herbal medicine to treat various diseases is becoming increasingly important as an alternative therapy. Numerous plants have been traditionally used for different purposes, including antiparasitic in humans and animals. Diseases caused by gastrointestinal parasites in ruminants, especially by the nematode Haemonchus contortus, cause large economic losses to the producers, whether by complications of the diseases or the cost of treatment. The main way of handling nematodiasis is by administering anthelmintic drugs, but their excessive use has the disadvantage of causing drug resistance; therefore, an alternative is the use of herbal medicine for this purpose. Mesquite (Prosopis spp.) has been used in Mexico to treat gastrointestinal diseases attributed to helminths. The present study aimed to characterize the rheological properties of mesquite flour using the SeDeM Expert System to determine its suitability for tablet production by direct compression. Direct compression technology facilitates the tableting process by reducing manufacturing costs. The results of the present study indicate that mesquite flour can be processed by direct compression. The latter could allow the manufacturing of economic tablets to treat infections by H. contortus in ruminants.
草药治疗各种疾病的用途作为替代疗法变得越来越重要。许多植物一直被传统用于不同的用途，包括人类和动物的驱虫。反刍动物的胃肠道寄生虫引起的疾病，特别是旋毛虫线虫 Haemonchus contortus 引起的疾病，会给生产者造成巨大的经济损失，无论是疾病的并发症还是治疗费用。处理线虫病的主要方法是使用驱虫药，但过度使用会导致抗药性；因此，一种替代方法是使用草药来达到这个目的。龙舌兰（Prosopis spp.）在墨西哥被用于治疗归因于寄生虫的胃肠道疾病。本研究旨在使用 SeDeM Expert System 来表征龙舌兰粉的流变特性，以确定其是否适合通过直接压缩生产片剂。直接压缩技术通过降低制造成本来促进压片过程。本研究的结果表明，龙舌兰粉可以通过直接压缩来处理。后者可以制造出经济实惠的片剂，用于治疗反刍动物感染旋毛虫。
