Folkers K, Wolaniuk A
Drugs Exp Clin Res. 1985;11(8):539-45.
Coenzyme Q10 (CoQ10) is a redox component in the respiratory chain. CoQ10 is necessary for human life to exist; and a deficiency can be contributory to ill health and disease. A deficiency of CoQ10 in myocardial disease has been found and controlled therapeutic trials have established CoQ10 as a major advance in the therapy of resistant myocardial failure. The cardiotoxicity of adriamycin, used in treatment modalities of cancer, is significantly reduced by CoQ10, apparently because the side-effects of adriamycin include inhibition of mitochondrial CoQ10 enzymes. Models of the immune system including phagocytic rate, circulating antibody level, neoplasia, viral and parasitic infections were used to demonstrate that CoQ10 is an immunomodulating agent. It was concluded that CoQ10, at the mitochondrial level, is essential for the optimal function of the immune system.
辅酶Q10（CoQ10）是呼吸链中的一种氧化还原成分。CoQ10是人类生命存在所必需的；缺乏它可能导致健康问题和疾病。已发现心肌病中存在CoQ10缺乏，且对照治疗试验已证实CoQ10是治疗难治性心肌衰竭的一项重大进展。用于癌症治疗的阿霉素的心脏毒性可被CoQ10显著降低，显然是因为阿霉素的副作用包括抑制线粒体CoQ10酶。包括吞噬率、循环抗体水平、肿瘤形成、病毒和寄生虫感染在内的免疫系统模型被用于证明CoQ10是一种免疫调节剂。得出的结论是，在细胞线粒体水平上，CoQ10对免疫系统的最佳功能至关重要。
