Ozdemir Emrah, Stavileci Berna, Ozdemir Bahar, Aksoy Faik Alper, Kahraman Serkan, Colakoglu Gevher Ceyla Zeynep, Ziyrek Murat, Dogan Ali
Department of Cardiology, Biruni University Faculty of Medicine, Küçükçekmece, Istanbul, Turkey.
Department of Cardiology, Biruni University Faculty of Medicine, Küçükçekmece, Istanbul, Turkey.
Adv Med Sci. 2024 Mar;69(1):56-60. doi: 10.1016/j.advms.2024.02.003. Epub 2024 Feb 17.
Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor beta superfamily and is faintly expressed under healthy conditions. GDF-15 is markedly elevated in a variety of diseases, including coronary artery disease (CAD), atrial fibrillation and heart failure. Here, we aimed to investigate the association of GDF-15 with the extent and severity of CAD in patients with stable CAD.
We enrolled 129 patients undergoing coronary angiography for the evaluation of stable CAD in the study. SYNTAX and SYNTAX II PCI/CABG scores were calculated. The CAD (+) study group was also stratified into two groups (high and low GDF-15) with respect to the mean GDF-15 value. Correlation and regression analyses were performed for further evaluation.
Of the 129 patients, 75 had CAD. GDF-15 values were higher in the CAD (+) group (p < 0.001). The two groups were compared according to a cut-off value of 2451.77. SYNTAX and SYNTAX II PCI/CABG scores were significantly associated with the high GDF-15 group (p < 0.001). Additionally, correlation analysis showed a strong positive correlation between GDF-15 and SYNTAX (r: 0.859, p < 0.001), SYNTAX II PCI (r: 0.921, p < 0.001) and SYNTAX II CABG (r: 0.874, p < 0.001) scores. Multivariate analysis identified GDF-15 as an independent predictor of CAD.
GDF-15 is an independent predictor of CAD and is associated with CAD severity in terms of SYNTAX, SYNTAX II PCI and SYNTAX II CABG scores.
生长分化因子15（GDF - 15）是转化生长因子β超家族的成员，在健康状态下表达微弱。GDF - 15在包括冠状动脉疾病（CAD）、心房颤动和心力衰竭在内的多种疾病中显著升高。在此，我们旨在研究GDF - 15与稳定型CAD患者CAD的范围和严重程度之间的关联。
我们纳入了129例接受冠状动脉造影以评估稳定型CAD的患者进行研究。计算SYNTAX和SYNTAX II PCI/CABG评分。CAD（+）研究组也根据平均GDF - 15值分为两组（高GDF - 15组和低GDF - 15组）。进行相关性和回归分析以进一步评估。
129例患者中，75例患有CAD。CAD（+）组的GDF - 15值更高（p < 0.001）。根据2451.77的临界值对两组进行比较。SYNTAX和SYNTAX II PCI/CABG评分与高GDF - 15组显著相关（p < 0.001）。此外，相关性分析显示GDF - 15与SYNTAX（r：0.859，p < 0.001）、SYNTAX II PCI（r：0.921，p < 0.001）和SYNTAX II CABG（r：0.874，p < 0.001）评分之间存在强正相关。多变量分析确定GDF - 15为CAD的独立预测因子。
GDF - 15是CAD的独立预测因子，并且在SYNTAX、SYNTAX II PCI和SYNTAX II CABG评分方面与CAD严重程度相关。
