Ferucci Elizabeth D, Holck Peter
Research Services Department, Division of Community Health Services, Alaska Native Tribal Health Consortium, 3900 Ambassador Drive, 2nd floor Anchorage, 99508, Anchorage, AK, USA.
BMC Rheumatol. 2024 Feb 18;8(1):7. doi: 10.1186/s41927-024-00377-8.
There is an increased risk of cardiovascular disease in people with many rheumatic diseases. The primary objective of this study was to evaluate cardiovascular disease hospitalizations in Alaska for people with and without a rheumatic disease diagnosis and assess disparities by race, with a focus on Alaska Native and American Indian people.
This study used the Alaska Health Facilities Data Reporting Program data on inpatient hospitalizations from 2015 to 2018. We identified people with a rheumatic disease diagnosis based on any hospitalization with a set of rheumatic disease diagnoses and compared them to people hospitalized but without a rheumatic disease diagnosis. We determined the odds of cardiovascular disease hospitalization by rheumatic disease diagnosis and assessed the influence of race and other factors, using univariate analyses and multivariable models.
People with a rheumatic disease diagnosis other than osteoarthritis had higher odds of cardiovascular disease hospitalization. The odds ratio was highest in people with gout compared to other rheumatic diseases. In multivariable models, there was an interaction between race and rheumatic disease status. Specifically, having gout increased the odds of cardiovascular disease hospitalization for people of all races, while having a rheumatic disease other than gout or osteoarthritis increased the odds of cardiovascular disease hospitalization in Alaska Native/American Indian people but not in people of other races.
The association between rheumatic disease status and cardiovascular disease hospitalization in Alaska varied by type of rheumatic disease and race. This adds substantially to the literature on associations between rheumatic disease and cardiovascular disease in Indigenous North American populations.
许多风湿性疾病患者患心血管疾病的风险增加。本研究的主要目的是评估阿拉斯加有或没有风湿性疾病诊断的人群的心血管疾病住院情况，并按种族评估差异，重点关注阿拉斯加原住民和美国印第安人。
本研究使用了阿拉斯加卫生设施数据报告计划中2015年至2018年住院患者的数据。我们根据一系列风湿性疾病诊断的任何住院情况确定患有风湿性疾病诊断的人群，并将他们与住院但没有风湿性疾病诊断的人群进行比较。我们通过风湿性疾病诊断确定心血管疾病住院的几率，并使用单变量分析和多变量模型评估种族和其他因素的影响。
除骨关节炎外，患有风湿性疾病诊断的人群心血管疾病住院几率更高。与其他风湿性疾病相比，痛风患者的优势比最高。在多变量模型中，种族与风湿性疾病状态之间存在相互作用。具体而言，痛风增加了所有种族人群心血管疾病住院的几率，而患有除痛风或骨关节炎以外的风湿性疾病增加了阿拉斯加原住民/美国印第安人心血管疾病住院的几率，但其他种族人群没有增加。
阿拉斯加风湿性疾病状态与心血管疾病住院之间的关联因风湿性疾病类型和种族而异。这大大增加了北美原住民人群中风湿性疾病与心血管疾病之间关联的文献。
