Hu Changlun, Yang Mei
Department of Internal Medicine, Chongqing Nanan District Traditional Chinese and Western Medicine Hospital, Chongqing, China.
Front Nutr. 2024 Feb 2;11:1328136. doi: 10.3389/fnut.2024.1328136. eCollection 2024.
The focus of this survey is on survey data for adults aged 20 and above, covering nine survey cycles from 2001 to 2018. Additionally, the present study explored the correlation between vitamin D concentrations and both cardiovascular disease (CVD) and all-cause mortality.
The objectives of this study were to evaluate the trend of changes in the serum 25(OH)D concentration changes in US adults during the survey period, the prevalence of vitamin D deficiency, and the current status of vitamin D dietary intake and supplementation.
In-home health interviews were performed using meticulously designed questionnaires that gathered information on demographic details, socioeconomic conditions, dietary patterns, and overall health status. Health assessments were conducted in specially designed mobile centers.
Survey data from 2001 to 2018 revealed a rise in serum 25(OH)D levels, from a weighted mean (95% CI) of 65.6 (63.8-67.4) nmol/L during 2001-2002 to 73.5 (70.4-76.5) nmol/L during 2017-2018, among US adults, while overall vitamin D deficiency rates remained stable ( = 0.152). Notably, in adults aged 20-39, 25(OH)D levels decreased ( = 0.002 for trend), and 25(OH)D deficiency increased ( = 0.003 for trend), especially among those with low incomes (deficiency >30%). Upon multivariable adjustment, an L-shaped relationship was found between serum 25(OH)D concentrations and both CVD and all-cause mortality ( < 0.001 for nonlinearity), as corroborated by sensitivity analyses.
From 2001 to 2018, US adults experienced a significant increase in their serum 25(OH) D concentration. However, subgroups of individuals, including young adults and individuals with lower socioeconomic status, exhibited a heightened risk of 25(OH)D deficiency. Furthermore, an L-shaped relationship was found between 25(OH)D concentration and both all-cause and CVD mortality among US adults.
本次调查的重点是20岁及以上成年人的调查数据，涵盖了2001年至2018年的九个调查周期。此外，本研究还探讨了维生素D浓度与心血管疾病（CVD）和全因死亡率之间的相关性。
本研究的目的是评估调查期间美国成年人血清25（OH）D浓度变化趋势、维生素D缺乏症患病率以及维生素D膳食摄入和补充的现状。
使用精心设计的问卷进行家庭健康访谈，收集有关人口统计学细节、社会经济状况、饮食模式和整体健康状况的信息。在专门设计的移动中心进行健康评估。
2001年至2018年的调查数据显示，美国成年人血清25（OH）D水平有所上升，从2001 - 2002年的加权平均值（95%CI）65.6（63.8 - 67.4）nmol/L升至2017 - 2018年的73.5（70.4 - 76.5）nmol/L，而总体维生素D缺乏率保持稳定（P = 0.152）。值得注意的是，在20 - 39岁的成年人中，25（OH）D水平下降（趋势P = 0.002），25（OH）D缺乏症增加（趋势P = 0.003），尤其是低收入者（缺乏率>30%）。多变量调整后，血清25（OH）D浓度与CVD和全因死亡率之间呈L形关系（非线性P < 0.001），敏感性分析证实了这一点。
2001年至2018年，美国成年人血清25（OH）D浓度显著增加。然而，包括年轻人和社会经济地位较低的个体在内的亚组人群，25（OH）D缺乏风险较高。此外，在美国成年人中，发现25（OH）D浓度与全因死亡率和CVD死亡率之间呈L形关系。
