Suppr超能文献

[吸入性支气管肺炎]

[Aspiration bronchopneumopathies].

作者信息

Battistini A, Grzincich G L, Pistocchi S, Rollo M

出版信息

Pediatr Med Chir. 1985 May-Jun;7(3):357-65.

PMID:3837199
Abstract

Diagnosis of pulmonary disease due to inhalation (PDI) is based on the assumption that not all paediatric pulmonary disease is attributable to infection. Moreover, an accurate investigation of all typical signs of PDI is necessary: drooling, pouring of food from the nose, choking, frequent vomiting and regurgitation. Specific aetiological diagnosis is not difficult when PDI represents only the epiphenomenon of well defined diseases which have disturbed deglutition (e.g. premature birth, cerebral palsy, muscle disease). It is difficult but more important to find the cause of dysphagia when dysphagia itself represents the first sign of dysfunction of the autonomic nervous system (e.g. familial dysautonomy). There are different PDI due to oesophageal dysphagia, e.g. the anomalous artery which presses the oesophagus against the trachea, oesophageal duplication, achalasia. The most frequent cause is gastro-oesophageal reflux, although recently its role in producing symptoms at night in the asthmatic child in much less. Gastro-oesophageal reflux is increased by the Beta2, agonists, the corticosteroids and theophylline. Therefore these drugs, especially theophylline, have to be used with discretion, also if gastro-oesophageal reflux is only suspected (e.g. frequent vomiting by the infant). Anomalous communication between the oesophagus and airways, particularly the laryngotracheo-oesophageal cleft and the isolated tracheoesophageal fistula, are rare diseases and difficult to diagnose. Therefore diagnosis can be delayed for months or even years. Prognosis is extremely variable: repeated inhalation will, however, cause diffuse interstitial fibrosis or, more rarely, a bronchiectasic lesion.

摘要

吸入性肺病(PDI)的诊断基于并非所有儿童肺病都归因于感染这一假设。此外,对PDI的所有典型体征进行准确调查是必要的:流口水、食物从鼻子流出、呛噎、频繁呕吐和反流。当PDI仅为明确的吞咽障碍疾病(如早产、脑瘫、肌肉疾病)的附带现象时,特异性病因诊断并不困难。当吞咽障碍本身是自主神经系统功能障碍(如家族性自主神经功能异常)的首要体征时,找出吞咽困难的原因虽困难但更为重要。因食管吞咽困难可导致不同类型的PDI,例如异常动脉将食管压向气管、食管重复畸形、贲门失弛缓症。最常见的原因是胃食管反流,不过最近其在哮喘儿童夜间症状产生中的作用已小得多。β2激动剂、皮质类固醇和茶碱会加重胃食管反流。因此,这些药物,尤其是茶碱,即使仅怀疑存在胃食管反流(如婴儿频繁呕吐)时,也必须谨慎使用。食管与气道之间的异常连通,特别是喉气管食管裂和孤立性气管食管瘘,是罕见疾病且难以诊断。因此,诊断可能会延迟数月甚至数年。预后差异极大:然而,反复吸入会导致弥漫性间质性纤维化,或更罕见的支气管扩张性病变。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验