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[两种不同学龄人群中血液嗜酸性粒细胞增多与过敏性呼吸道疾病的关系]

[Relation between blood eosinophilia and allergic respiratory disease in 2 different school-age populations].

作者信息

Altobelli R, Obino G, Vercesi A M

出版信息

Pediatr Med Chir. 1985 May-Jun;7(3):413-7.

PMID:3837202
Abstract

Two groups of children from 6 to 14 years old have been compared to explain correlation between haematic eosinophils and allergic respiratory diseases related with the environment where they live. First group was formed by 350 pupils of Sesto S. Giovanni, and industrialized town, the second group by 345 pupils of Cogliate, a country place. The screening was been preceded by a set of questions self-managed and it consisted in the determinations percentage of peripheral blood eosinophils. Patients whose eosinophils were more than 4% have been considered eosinophilia carrier. The results have been elaborated with statistical method "chi square". Results proved the greatest prevalence of allergic respiratory diseases in urban population with a greater eosinophilia spreading (33% in comparison with 26%; p less than 0.05). Eosinophilia appeared connected with recurrent rhinitis (p less than 0.001) relapsing bronchitis (p less than 0.001) relapsing bronchitis (p less than 0.001) asthmatic bronchitis (p less than 0.001) positive results of skin tests to 4 allergens (p less than 0.001) and in rural district also with male sex (p less than 0.05). In industrialized areas, in special way there is a closed relation between respiratory diseases and peripheral blood eosinophils increased. Eosinophilia will be find in relapsing respiratory pathology and it will apply to allergology controls. It could represent an unfavourable element of prognosis foresee the possibility that episodic bronchus-spasms will be frequent in patients with asthmatic syndrome.

摘要

为解释血液嗜酸性粒细胞与他们所生活环境相关的过敏性呼吸道疾病之间的相关性,对两组6至14岁的儿童进行了比较。第一组由350名来自工业化城镇塞斯托圣乔瓦尼的学生组成,第二组由345名来自乡村科利亚泰的学生组成。在筛查之前,先进行了一组自行管理的问题调查,调查内容包括外周血嗜酸性粒细胞的百分比测定。嗜酸性粒细胞超过4%的患者被视为嗜酸性粒细胞增多症携带者。结果采用“卡方”统计方法进行阐述。结果证明,城市人群中过敏性呼吸道疾病的患病率更高,嗜酸性粒细胞增多症的分布也更广(分别为33%和26%;p小于0.05)。嗜酸性粒细胞增多症似乎与复发性鼻炎(p小于0.001)、复发性支气管炎(p小于0.001)、哮喘性支气管炎(p小于0.001)、对4种变应原皮肤试验呈阳性结果(p小于0.001)有关,在农村地区还与男性性别有关(p小于0.05)。在工业化地区,特别是呼吸系统疾病与外周血嗜酸性粒细胞增多之间存在密切关系。嗜酸性粒细胞增多症将出现在复发性呼吸道疾病中,并适用于变态反应学检查。它可能代表一个不利的预后因素,预示着哮喘综合征患者发作性支气管痉挛频繁发作的可能性。

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