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作者信息

Mensi Sihem, Ezzine Abir, Dardouri Teheni, Ben Rejeb Mohamed, Ben Fredj Maha, Chatti Kaouther

机构信息

Nuclear Medicine Department, Sahloul Hospital, Sousse, Tunisia.

"LR12ES02" Research Laboratory, Department of Biophysics, Ibn El Jazzar Sousse Faculty of Medicine, University of Sousse, Tunisia.

出版信息

Tunis Med. 2023 May 5;101(5):521-526.

DOI:

PMID:38372523

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11361298/

Abstract

INTRODUCTION

Differentiated thyroid cancer (DTC), despite its good prognosis, affects the quality of life (QOL) of patients by its physical and psychological repercussions and by the toxicity of treatment. A study of the quality of life as well as the potentially associated factors is necessary in order to carry out targeted actions.

AIM

This work was conducted to assess the quality of life of patients treated for thyroid cancer.

METHODS

89 patients treated surgically and by iratherapy for DTC responded from January 2018 to December 2019 to the SF36 questionnaire in its validated version in Tunisian dialect. A descriptive and bivariate analysis between the scores of the different domains and the variables of interest was performed.

RESULTS

The overall mean score (SMG) of the QOL of our patients ranged from 12.8 to 94.25 with a mean of 58±22%. The factors that proved to have a positive impact on the QOL of patients followed for CDT assessed by the SMG and/or the mental summary score (MSS) and/or the physical summary score (PSS) were: male gender (p=0.034), higher educational level (p=0.037), early TNM stage (p=0.041) and low cumulative iodine-131 dose (≤ 5550 MBq) (p=0.031).

CONCLUSION

QOL is strongly influenced by many sociodemographic and clinical factors. More attention should be paid to patients followed for DTC to improve quality of life.

摘要

引言

分化型甲状腺癌（DTC）尽管预后良好，但因其对身体和心理的影响以及治疗的毒性，会影响患者的生活质量（QOL）。为了采取有针对性的行动，有必要对生活质量及其潜在相关因素进行研究。

目的

开展这项工作以评估接受甲状腺癌治疗的患者的生活质量。

方法

2018年1月至2019年12月期间，89例接受手术和碘治疗的DTC患者用突尼斯方言的有效版本对SF36问卷进行了回应。对不同领域的得分与感兴趣的变量进行了描述性和双变量分析。

结果

我们患者的生活质量总体平均得分（SMG）在12.8至94.25之间，平均为58±22%。经SMG和/或心理综合评分（MSS）和/或身体综合评分（PSS）评估，被证明对接受CDT治疗的患者的生活质量有积极影响的因素有：男性（p = 0.034）、较高的教育水平（p = 0.037）、早期TNM分期（p = 0.041）和低累积碘-131剂量（≤5550 MBq）（p = 0.031）。