School of Medicine, Tzu Chi University, Hualien, Taiwan.
Department of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Curr Rheumatol Rep. 2024 May;26(5):188-195. doi: 10.1007/s11926-024-01139-8. Epub 2024 Feb 19.
The purpose of this literature review was to determine if medications used to treat osteoporosis are also effective for treating osteoarthritis (OA).
A total of 40 relevant articles were identified. Studies were categorized into those (1) discussing estrogen and selective estrogen receptor modulators (SERMs), (2) bisphosphonates, (3) parathyroid hormone (PTH) analogs, and (4) denosumab, and (5) prior review articles. A large amount of evidence suggests that estrogen and SERMs are effective at reducing OA symptoms and disease progression. Evidence suggests that bisphosphonates, the most common medications used to treat osteoporosis, can reduce OA symptoms and disease progression. In vivo studies suggest that PTH analogs may improve the cartilage destruction associated with OA; however, few human trials have examined its use for OA. Denosumab is approved to treat osteoporosis, bone metastases, and certain types of breast cancer, but little study has been done with respect to its effect on OA. The current evidence indicates that medications used to treat osteoporosis are also effective for treating OA. Estrogen, SERMs, and bisphosphonates have the most potential as OA therapies. Less is known regarding the effectiveness of PTH analogs and denosumab in OA, and more research is needed.
本文旨在确定治疗骨质疏松症的药物是否也能有效治疗骨关节炎（OA）。
共确定了 40 篇相关文章。研究分为五类：（1）讨论雌激素和选择性雌激素受体调节剂（SERMs）；（2）双膦酸盐；（3）甲状旁腺激素（PTH）类似物；（4）地舒单抗；（5）先前的综述文章。大量证据表明，雌激素和 SERMs 可有效减轻 OA 症状和疾病进展。有证据表明，双膦酸盐是治疗骨质疏松症最常用的药物之一，可减轻 OA 症状和疾病进展。体内研究表明，PTH 类似物可能改善与 OA 相关的软骨破坏；然而，很少有人类试验研究其用于 OA 的效果。地舒单抗已获准用于治疗骨质疏松症、骨转移和某些类型的乳腺癌，但对其治疗 OA 的效果研究甚少。目前的证据表明，治疗骨质疏松症的药物对治疗 OA 也有效。雌激素、SERMs 和双膦酸盐作为 OA 治疗药物最具潜力。对于 PTH 类似物和地舒单抗在 OA 中的有效性知之甚少，需要更多的研究。
