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袖状胃切除术对味觉食欲域的影响：采用递进比率任务。

The Effects of Sleeve Gastrectomy on the Appetitive Domain of Taste Using the Progressive Ratio Task.

机构信息

Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

Division of Diabetes, Endocrinology and Metabolism, Imperial College London, 5, London, UK.

出版信息

Obes Surg. 2024 Apr;34(4):1168-1173. doi: 10.1007/s11695-023-07035-x. Epub 2024 Feb 19.

DOI:10.1007/s11695-023-07035-x
PMID:38372880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11026271/
Abstract

INTRODUCTION

Sleeve gastrectomy (SG) is an effective treatment for obesity in adolescents. The underlying weight loss mechanism may impact the peripheral and central gustatory system along with reward circuits in the brain. This study aims to assess changes in appetitive behavior in short-, medium-, and long-term follow-up.

METHODS

In this prospective observational study, a total of 8 adolescents with obesity who underwent SG and 9 comparator unoperated participants were studied. Appetitive behaviour towards fat and sweet taste stimuli was assessed using the Progressive Ratio Task (PRT) over a 6 year period.

RESULTS

Mean body mass index (BMI) of the surgical patients dropped from 51.5 ± 2.8 kg/m to 31.4 ± 1.9 and 30.9 ± 2.3 kg/m at 1 and 6 years follow-up, respectively. (p < 0.001). The median (interquartile range) total rewards earned during the PRT was 6 (5-7) pre-surgery, 5 (3-6) after one year and 4 (2-4) after six years from surgery (p = 0.007).

CONCLUSION

SG reduced appetitive behaviour at 1 year with maintained the benefit over 6 years as measured by the progressive ratio task.

摘要

简介

袖状胃切除术（SG）是治疗青少年肥胖的有效方法。潜在的减肥机制可能会影响外周和中枢味觉系统以及大脑中的奖励回路。本研究旨在评估短期、中期和长期随访中食欲行为的变化。

方法

在这项前瞻性观察研究中，共纳入 8 名接受 SG 治疗的肥胖青少年患者和 9 名未手术的对照组参与者。使用递增比率任务（PRT）评估脂肪和甜味味觉刺激的食欲行为，随访时间为 6 年。

结果

手术患者的平均体重指数（BMI）从 51.5±2.8kg/m降至术后 1 年的 31.4±1.9kg/m 和 6 年的 30.9±2.3kg/m（p<0.001）。PRT 中获得的总奖励中位数（四分位距）分别为术前 6（5-7）、术后 1 年 5（3-6）和术后 6 年 4（2-4）（p=0.007）。

结论

SG 在术后 1 年降低了食欲行为，6 年后仍保持这种益处，这可以通过递增比率任务来衡量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4020/11026271/9364da747b2c/11695_2023_7035_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4020/11026271/d01ddcd58390/11695_2023_7035_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4020/11026271/4e51a57b3b38/11695_2023_7035_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4020/11026271/9364da747b2c/11695_2023_7035_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4020/11026271/d01ddcd58390/11695_2023_7035_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4020/11026271/4e51a57b3b38/11695_2023_7035_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4020/11026271/9364da747b2c/11695_2023_7035_Fig3_HTML.jpg

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本文引用的文献

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J Am Coll Surg. 2021 Dec;233(6):657-664. doi: 10.1016/j.jamcollsurg.2021.08.678. Epub 2021 Sep 23.
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Novel Methodological Considerations Regarding the Use of Visual Analog Scale (VAS) Appetite Questionnaires in Tightly Controlled Feeding Trials.关于在严格控制的喂养试验中使用视觉模拟量表（VAS）食欲问卷的新方法学考量。
Curr Dev Nutr. 2019 May 2;3(6):nzz061. doi: 10.1093/cdn/nzz061. eCollection 2019 Jun.
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Surg Obes Relat Dis. 2019 Feb;15(2):194-199. doi: 10.1016/j.soard.2018.10.033. Epub 2018 Nov 22.
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Difficulties in Translating Appetite Sensations Effect of Turmeric-Based Beverage When Given Prior to Isoenergetic Medium- or High-Fat Meals in Healthy Subjects.健康受试者中，给予能量相等的中-高脂肪餐之前摄入姜黄基饮料对食欲感知的影响：翻译难点。
Nutrients. 2019 Mar 29;11(4):736. doi: 10.3390/nu11040736.
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