Environmental Health Laboratory, Institut Pasteur du Maroc, Morocco; Laboratory of Chemistry, Biochemistry, Nutrition, and Environment, Faculty of Medicine and Pharmacy, University Hassan II, Casablanca, Morocco.
African genome center, Mohammed VI Polytechnic University, Bengurir, 43 150, Morocco.
Diabetes Metab Syndr. 2024 Feb;18(2):102965. doi: 10.1016/j.dsx.2024.102965. Epub 2024 Feb 11.
The association of the C677T polymorphism of the Methylenetetrahydrofolate Reductase (MTHFR) gene with susceptibility to type 2 diabetes mellitus (T2DM) has been widely debated. Therefore, our aim is to conclusively resolve this controversy in the Middle East and North Africa region population through a meta-analysis.
We identified relevant articles by searching literature databases, such as PubMed, Web of Science, and Science Direct, to retrieve studies that examined the association between the MTHFR C677T polymorphism and the risk of developing T2DM. Using meta-analysis, we calculated the odds ratio (OR) and confidence interval (CI) values of these studies to assess the susceptibility to T2DM related to the C677T polymorphism of MTHFR gene.
In this meta-analysis, we included a total of 13 publications comprising 2072 T2DM patients and 2164 control subjects. The results of the meta-analysis suggested that there is a significant association between the C677T polymorphism and T2DM risk in overall comparisons for allele contrasts (T vs C): OR = 1.25, 95% CI = 1.04-1.50, p = 0.015 and homozygous (TT vs CC): OR = 1.44, 95% CI = 1.01-2.05, p = 0.038). Subgroup analysis revealed that the C677T polymorphism is associated with a risk of T2DM in Asian populations, while there is no significant association between this polymorphism and T2DM in Caucasian and African populations. Furthermore, there was no evidence of publication bias.
Our study's results suggest that the allele contrast of the C677T polymorphism of the MTHFR gene is associated with an increased risk of T2DM in the overall population, particularly among Asians.
亚甲基四氢叶酸还原酶（MTHFR）基因 C677T 多态性与 2 型糖尿病（T2DM）易感性的关联存在广泛争议。因此，我们旨在通过荟萃分析，明确解决中东和北非地区人群中的这一争议。
我们通过检索文献数据库（如 PubMed、Web of Science 和 Science Direct）来确定相关文献，以检索研究 MTHFR C677T 多态性与 T2DM 发病风险之间关系的文章。使用荟萃分析，我们计算了这些研究的比值比（OR）和置信区间（CI）值，以评估 MTHFR 基因 C677T 多态性与 T2DM 易感性的关系。
在这项荟萃分析中，我们共纳入了 13 项研究，共包括 2072 例 T2DM 患者和 2164 例对照。荟萃分析的结果表明，在总体比较中，C677T 多态性与 T2DM 风险之间存在显著关联，等位基因对比（T 对 C）：OR=1.25，95%CI=1.04-1.50，p=0.015；纯合子（TT 对 CC）：OR=1.44，95%CI=1.01-2.05，p=0.038。亚组分析显示，C677T 多态性与亚洲人群 T2DM 发病风险相关，而在高加索人群和非洲人群中，该多态性与 T2DM 之间无显著相关性。此外，没有证据表明存在发表偏倚。
本研究结果表明，MTHFR 基因 C677T 多态性的等位基因对比与总体人群 T2DM 风险增加相关，尤其是在亚洲人群中。
