Department of Pulmonary and Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Department of Pulmonary and Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Center of Community-Based Health Research, Fudan University, Shanghai, China.
Int Immunopharmacol. 2024 Mar 30;130:111670. doi: 10.1016/j.intimp.2024.111670. Epub 2024 Feb 18.
Type 2 immune responses are critical for host defense, mediate allergy and Th2-high asthma. The transcription factor, promyelocytic leukemia zinc finger (PLZF), has emerged as a significant regulator of type 2 inflammation in the lung; however, its exact mechanism remains unclear. In this review, we summarized recent findings regarding the ability of PLZF to control the development and function of innate lymphoid cells (ILCs), iNKT cells, memory T cells, basophils, and other immune cells that drive type 2 responses. We discussed the important role of PLZF in the pathogenesis of Th2-high asthma. Collectively, prior studies have revealed the critical role of PLZF in the regulation of innate and adaptive immune cells involved in type 2 inflammation in the lung. Therefore, targeting PLZF signaling represents a promising therapeutic approach to suppress Th2-high asthma.
2 型免疫反应对于宿主防御至关重要，介导过敏和 2 型高反应性哮喘。转录因子早幼粒细胞白血病锌指蛋白（PLZF）已成为肺部 2 型炎症的重要调节因子，但确切机制尚不清楚。在这篇综述中，我们总结了最近关于 PLZF 控制先天淋巴细胞（ILC）、iNKT 细胞、记忆 T 细胞、嗜碱性粒细胞和其他驱动 2 型反应的免疫细胞的发育和功能的能力的发现。我们讨论了 PLZF 在 2 型高反应性哮喘发病机制中的重要作用。总之，先前的研究表明 PLZF 在调节肺部 2 型炎症中涉及的先天和适应性免疫细胞方面发挥着关键作用。因此，靶向 PLZF 信号转导可能是抑制 2 型高反应性哮喘的一种有前途的治疗方法。
