Kovalovsky Damian, Uche Olisambu U, Eladad Sonia, Hobbs Robin M, Yi Woelsung, Alonzo Eric, Chua Kevin, Eidson Maggie, Kim Hye-Jung, Im Jin S, Pandolfi Pier Paolo, Sant'Angelo Derek B
Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Nat Immunol. 2008 Sep;9(9):1055-64. doi: 10.1038/ni.1641. Epub 2008 Jul 27.
Invariant natural killer T cells (iNKT cells) have an innate immunity-like rapidity of response and the ability to modulate the effector functions of other cells. We show here that iNKT cells specifically expressed the BTB-zinc finger transcriptional regulator PLZF. In the absence of PLZF, iNKT cells developed, but they lacked many features of innate T cells. PLZF-deficient iNKT cells accumulated in lymph nodes rather than in the liver, did not express NK markers and did not have the characteristic activated phenotype. PLZF-deficient iNKT cells failed to secrete large amounts of interleukin 4 and interferon-gamma after activation; however, some cells produced either interleukin 4 or interferon-gamma but not both. PLZF, therefore, is an iNKT cell-specific transcription factor that is necessary for full functionality.
不变自然杀伤T细胞（iNKT细胞）具有类似先天免疫的快速反应能力以及调节其他细胞效应功能的能力。我们在此表明，iNKT细胞特异性表达BTB-锌指转录调节因子PLZF。在缺乏PLZF的情况下，iNKT细胞能够发育，但缺乏先天T细胞的许多特征。缺乏PLZF的iNKT细胞积聚在淋巴结而非肝脏中，不表达NK标志物，也不具有特征性的活化表型。缺乏PLZF的iNKT细胞在激活后无法分泌大量白细胞介素4和干扰素-γ；然而，一些细胞只能产生白细胞介素4或干扰素-γ，而不能同时产生两者。因此，PLZF是一种iNKT细胞特异性转录因子，是iNKT细胞发挥全部功能所必需的。
