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[2016 - 2018年法国产科出血导致的孕产妇死亡情况]

[Maternal mortality due to obstetric haemorrhage in France 2016-2018].

作者信息

Verspyck Eric, Morau Estelle, Chiesa-Dubruille Coralie, Bonnin Martine

机构信息

Service de gynécologie-obstétrique, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.

Service d'anesthésie-réanimation, CHU de Nîmes, Nîmes, France.

出版信息

Gynecol Obstet Fertil Senol. 2024 Apr;52(4):238-245. doi: 10.1016/j.gofs.2024.02.016. Epub 2024 Feb 17.

Abstract

Between 2016 and 2018, 20 maternal deaths were related to obstetric haemorrhage, excluding haemorrhage in the first trimester of pregnancy, representing a mortality ratio of 0.87 per 100,000 live births (95% CI 0.5 -1.3). Obstetric haemorrhage is the cause of 7.4% of all maternal deaths up to 1 year, 10% of maternal deaths within 42days, and 21% of deaths directly related to pregnancy (direct causes). Between 2001 and 2018, maternal mortality from obstetric haemorrhage has been considerably reduced, from 2.2deaths per 100,000 live births in 2001-2003 to 0.87 in the period presented here. Nevertheless, obstetric haemorrhage is still one of the main direct causes of maternal death, and remains the cause with the highest proportion of deaths considered probably (53%) or possibly (42%) preventable according to the CNEMM's collegial assessment (see chapter 3). The preventable factors reported are related to inadequate content of care in 94% of cases and/or organisation of care in 44% of cases. In this triennium, maternal death due to haemorrhage occurred mainly in the context of caesarean delivery (65% of cases, i.e. 13/20), and mostly in the context of emergency care (12/13). The main causes of obstetric haemorrhage were uterine rupture (6/20) in unscarred uterus or in association with placenta accreta, and surgical injury during the caesarean delivery (5/20). Every maternity hospital, whatever its resources and/or technical facilities, must be able to plan any obstetric haemorrhage situation that threatens the mother's vital prognosis. Intraperitoneal occult haemorrhage following caesarean section and uterine rupture require immediate surgery with the help of skilled surgeon resources with early and appropriate administration of blood products.

摘要

2016年至2018年期间,有20例孕产妇死亡与产科出血相关(不包括妊娠早期出血),孕产妇死亡率为每10万例活产0.87例(95%置信区间0.5-1.3)。产科出血是1年内所有孕产妇死亡原因的7.4%,42天内孕产妇死亡原因的10%,以及与妊娠直接相关死亡原因(直接原因)的21%。2001年至2018年期间,产科出血导致的孕产妇死亡率大幅下降,从2001-2003年的每10万例活产2.2例死亡降至本文所述期间的0.87例。然而,产科出血仍是孕产妇死亡的主要直接原因之一,并且根据国家孕产妇死亡保密评审委员会(CNEMM)的合议评估,它仍然是被认为可能(53%)或有可能(42%)可预防的死亡原因中占比最高的原因(见第3章)。报告的可预防因素在94%的病例中与护理内容不足有关,和/或在44%的病例中与护理组织有关。在这三年期间,因出血导致的孕产妇死亡主要发生在剖宫产情况下(65%的病例,即13/20),并且大多发生在急诊情况下(12/13)。产科出血的主要原因是未受损子宫或合并胎盘植入时的子宫破裂(6/20),以及剖宫产手术期间的手术损伤(5/20)。每家妇产医院,无论其资源和/或技术设施如何,都必须能够应对任何威胁母亲生命预后的产科出血情况。剖宫产术后腹腔内隐匿性出血和子宫破裂需要在有经验的外科医生资源的帮助下立即进行手术,并尽早且适当地输注血液制品。

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