首例病例报告：通过支气管肺泡灌洗术（BALF）下一代测序诊断和治疗坏死梭杆菌肺脓肿
The first case report: diagnosis and management of necrotizing fusobacterium lung abscess via BALF next-generation sequencing.
作者信息
Liu Yang, Li Ziye, Fu Handan, Ruan Weiliang, Wang Hua, Ding Yuhong, Zhang Miao
机构信息
Respiratory Department, Shaoxing City Keqiao District Hospital of Traditional Chinese Medicine, 312030, Shaoxing, China.
Special Inspection Department, Shaoxing City Keqiao District Hospital of Traditional Chinese Medicine, 312030, Shaoxing, China.
出版信息
BMC Infect Dis. 2024 Feb 19;24(1):218. doi: 10.1186/s12879-024-09087-5.
BACKGROUND
Fusobacterium necrophorum (F. necrophorum)-induced necrotizing pneumonia is a rare but severe pulmonary infection. Insufficient microbiological detection methods can lead to diagnostic difficulties.
METHODS
We report a case of F. necrophorum lung abscess diagnosed by next-generation sequencing (NGS) of bronchoalveolar lavage fluid (BALF).
RESULTS
BALF-NGS detected F. necrophorum, guiding subsequent targeted antibiotic therapy. With active drainage and metronidazole treatment, the patient's condition was effectively treated.
CONCLUSION
BALF-NGS is a valuable tool for the rapid diagnosis of infections caused by difficult-to-culture bacteria. It played a decisive role in the early identification of F. necrophorum, enabling timely and targeted antibiotic intervention. Early diagnosis and appropriate treatment are crucial for the management of F. necrophorum pneumonia.
背景
坏死梭杆菌引起的坏死性肺炎是一种罕见但严重的肺部感染。微生物检测方法不足会导致诊断困难。
方法
我们报告一例通过支气管肺泡灌洗术（BALF）的二代测序（NGS）诊断出的坏死梭杆菌肺脓肿病例。
结果
BALF-NGS检测到坏死梭杆菌，指导了后续的靶向抗生素治疗。通过积极引流和甲硝唑治疗，患者病情得到有效治疗。
结论
BALF-NGS是快速诊断由难培养细菌引起的感染的有价值工具。它在坏死梭杆菌的早期识别中起了决定性作用，使得能够及时进行靶向抗生素干预。早期诊断和适当治疗对于坏死梭杆菌肺炎的管理至关重要。
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