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韩国年轻乳腺癌患者中BRCA检测的实施：一项全国性队列研究。

Implementation of BRCA Test among Young Breast Cancer Patients in South Korea: A Nationwide Cohort Study.

作者信息

Hwang Yung-Huyn, Yoo Tae-Kyung, Lee Sae Byul, Kim Jisun, Ko Beom Seok, Kim Hee Jeong, Lee Jong Won, Son Byung Ho, Chung Il Yong

机构信息

Division of Breast Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

Cancer Res Treat. 2024 Jul;56(3):802-808. doi: 10.4143/crt.2023.1186. Epub 2024 Feb 19.

DOI:10.4143/crt.2023.1186
PMID:38374698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11261184/
Abstract

PURPOSE

This study aimed to investigate the frequency of BRCA testing and related factors among young breast cancer patients (age < 40 years) in South Korea.

MATERIALS AND METHODS

We conducted a nationwide retrospective cohort study using data from the Health Insurance Review and Assessment claims. Newly diagnosed breast cancer patients younger than 40 were included. Annual BRCA testing ratios (number of BRCA test recipients/the number of patients undergoing breast cancer surgery in each year) were analyzed by region and health care delivery system. We investigated the location of breast cancer diagnosis and BRCA testing.

RESULTS

From January 2010 to December 2020, there were 25,665 newly diagnosed young breast cancer patients, of whom 12,186 (47.5%) underwent BRCA testing. The BRCA testing ratios increased gradually from 0.084 (154/1,842) in 2010 to 0.961 (1,975/2,055) in 2020. Medical aid (vs. health insurance) and undergoing surgery in metropolitan cities or others (vs. Seoul), general hospitals, and clinics (vs. tertiary hospitals) were associated with a lower likelihood of BRCA testing. While 97.8% of the patients diagnosed in Seoul underwent BRCA testing in Seoul, 22.9% and 29.2% of patients who were diagnosed in metropolitan areas and other regions moved to Seoul and underwent BRCA testing, respectively.

CONCLUSION

The frequency of BRCA testing has increased over time in South Korea, with Seoul showing a particularly high rate of testing. About one-quarter of patients diagnosed with breast cancer outside of Seoul moved to Seoul and underwent BRCA testing.

摘要

目的

本研究旨在调查韩国年轻乳腺癌患者（年龄<40岁）中BRCA检测的频率及相关因素。

材料与方法

我们利用健康保险审查与评估理赔数据进行了一项全国性回顾性队列研究。纳入年龄小于40岁的新诊断乳腺癌患者。按地区和医疗服务提供系统分析年度BRCA检测率（每年BRCA检测接受者人数/每年接受乳腺癌手术的患者人数）。我们调查了乳腺癌诊断和BRCA检测的地点。

结果

2010年1月至2020年12月，共有25665例新诊断的年轻乳腺癌患者，其中12186例（47.5%）接受了BRCA检测。BRCA检测率从2010年的0.084（154/1842）逐渐上升至2020年的0.961（1975/2055）。医疗救助（与健康保险相比）、在大城市或其他地区（与首尔相比）、综合医院和诊所（与三级医院相比）接受手术与BRCA检测可能性较低相关。在首尔诊断的患者中有97.8%在首尔接受了BRCA检测，而在大城市地区和其他地区诊断的患者分别有22.9%和29.2%前往首尔并接受了BRCA检测。

结论

韩国BRCA检测的频率随时间增加，首尔的检测率尤其高。在首尔以外地区诊断为乳腺癌的患者中，约四分之一前往首尔并接受了BRCA检测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab8/11261184/8cf961277031/crt-2023-1186f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab8/11261184/11fa6ca034e8/crt-2023-1186f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab8/11261184/0933a2571adb/crt-2023-1186f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab8/11261184/8cf961277031/crt-2023-1186f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab8/11261184/11fa6ca034e8/crt-2023-1186f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab8/11261184/0933a2571adb/crt-2023-1186f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab8/11261184/8cf961277031/crt-2023-1186f3.jpg

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韩国遗传咨询的当前问题、挑战和未来展望。
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Cancer Res Treat. 2022 Oct;54(4):1099-1110. doi: 10.4143/crt.2021.978. Epub 2021 Nov 17.
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Adjuvant Olaparib for Patients with - or -Mutated Breast Cancer.奥拉帕利辅助治疗 - 或 - 突变型乳腺癌患者。
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Examining the uptake of predictive BRCA testing in the UK; findings and implications.检查英国预测性 BRCA 检测的采用情况；调查结果及启示。
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