Hasan Sajibul, Miah Mohammad Alam, Mustari Afrina, Sujan Khaled Mahmud, Bhuiyan Md Eliusur Rahman, Rafiq Kazi
Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensing, 2202, Bangladesh.
Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensing, 2202, Bangladesh.
Heliyon. 2024 Feb 9;10(4):e25852. doi: 10.1016/j.heliyon.2024.e25852. eCollection 2024 Feb 29.
Several environmental pollutants, mostly chemicals and plasticizers, have an effect on the reproduction of small ruminants, causing abortion, delayed estrus, and decreased fertility. Phthalates are common in our environment and have been identified as endocrine disrupting chemicals (EDCs). The research work investigated the impact of dietary exposure to a phthalate mixture on physical and hemato-biochemical parameters in pregnant Black Bengal (BB) goats. A total of 20 clinically healthy, 1-2 months pregnant, aged 6-8 months with a body weight of 10-12 kg BB goats were collected and divided into two (n = 10) groups. The treatment group received a standard goat ration with a combination of different phthalates mixture while the control group was provided the same ration with the vehicle of aphthalatemixture until parturition. The physical parameters were measured with appropriate tools and blood samples were collected for hemato-biochemical tests. The results showed that the physiological parameters (body condition score, respiration rate and heart rate) were significantly (P < 0.05) reduced in phthalate-exposed goats without altering rectal temperature and rumen motility. The hematological parameters: RBC count, WBC count, hemoglobin concentration, hematocrit values and RBC indices were significantly (P < 0.05) lower in phthalate-exposed goats. Phthalate-exposed BB goats had significantly (P < 0.05) higher neutrophil and lower lymphocyte counts. Serum glucose, total protein, albumin and total cholesterol levels were significantly (P < 0.05) lower in phthalate-exposed BB goats but higher the values of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and blood urea nitrogen (BUN) levels in treated BB goats. It may be concluded that exposure to a phthalate mixture during pregnancy alters the physical, hematological and biochemical parameters in BB goats.
几种环境污染物，主要是化学物质和增塑剂，会对小型反刍动物的繁殖产生影响，导致流产、发情延迟和生育能力下降。邻苯二甲酸盐在我们的环境中很常见，并且已被确定为内分泌干扰化学物质（EDC）。这项研究工作调查了饮食中接触邻苯二甲酸盐混合物对怀孕的黑孟加拉（BB）山羊的身体和血液生化参数的影响。总共收集了20只临床健康、怀孕1 - 2个月、年龄6 - 8个月、体重10 - 12千克的BB山羊，并将它们分成两组（n = 10）。治疗组接受含有不同邻苯二甲酸盐混合物组合的标准山羊日粮，而对照组则给予含有邻苯二甲酸盐混合物载体的相同日粮直至分娩。使用适当的工具测量身体参数，并采集血样进行血液生化测试。结果表明，接触邻苯二甲酸盐的山羊的生理参数（身体状况评分、呼吸频率和心率）显著降低（P < 0.05），但直肠温度和瘤胃蠕动没有改变。血液学参数：红细胞计数、白细胞计数、血红蛋白浓度、血细胞比容值和红细胞指数在接触邻苯二甲酸盐的山羊中显著降低（P < 0.05）。接触邻苯二甲酸盐的BB山羊的中性粒细胞计数显著升高（P < 0.05），淋巴细胞计数降低。接触邻苯二甲酸盐的BB山羊的血清葡萄糖、总蛋白、白蛋白和总胆固醇水平显著降低（P < 0.05），但治疗组BB山羊的天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和血尿素氮（BUN）水平较高。可以得出结论，怀孕期间接触邻苯二甲酸盐混合物会改变BB山羊的身体、血液学和生化参数。
