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与产后抑郁症相关的遗传标记：综述

Genetic Markers Associated with Postpartum Depression: A Review.

作者信息

Chandra Joshua Harry, Kurniawan Candy, Puspitasari Irma Melyani

机构信息

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia.

Center of Excellence for Pharmaceutical Care Innovation, Universitas Padjadjaran, Sumedang, West Java, Indonesia.

出版信息

Neuropsychiatr Dis Treat. 2024 Feb 15;20:281-293. doi: 10.2147/NDT.S434165. eCollection 2024.

DOI:10.2147/NDT.S434165
PMID:38375417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10876008/
Abstract

Postpartum depression (PPD) is a common illness in mothers after childbirth. PPD negatively affect the mother's quality of life and the bond with the infant, which can interfere with the infant's emotional, social, and cognitive development. PPD is caused by various biological and psychosocial factors. The aim of this review is to summarize the latest evidence of the associations between genetic polymorphisms and PPD. PubMed and Scopus were used as the literature search databases for this review. The keywords used were postpartum depression, postnatal depression, genetic, and polymorphism. Twenty-seven articles were reviewed after screening and applying the inclusion criteria. As results, the serotonin gene () and oxytocin genes () have the most significant associations with PPD among other genes. Further research on PPD biomarkers should be conducted to diagnose and treat PPD patients.

摘要

产后抑郁症（PPD）是产后母亲中常见的疾病。PPD会对母亲的生活质量以及与婴儿的亲密关系产生负面影响，进而可能干扰婴儿的情感、社交和认知发展。PPD由多种生物和心理社会因素引起。本综述的目的是总结基因多态性与PPD之间关联的最新证据。本综述使用PubMed和Scopus作为文献搜索数据库。使用的关键词为产后抑郁症、产后抑郁、基因和多态性。在筛选并应用纳入标准后，共审查了27篇文章。结果显示，血清素基因（）和催产素基因（）与PPD的关联在其他基因中最为显著。应进一步开展关于PPD生物标志物的研究，以诊断和治疗PPD患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f03/10876008/a81a0aceb598/NDT-20-281-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f03/10876008/a81a0aceb598/NDT-20-281-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f03/10876008/a81a0aceb598/NDT-20-281-g0001.jpg

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本文引用的文献

1
Correlations between GRIN2B and GRIN3A gene polymorphisms and postpartum depressive symptoms in Chinese parturients undergoing cesarean section: A prospective cohort study.GRIN2B 和 GRIN3A 基因多态性与行剖宫产术的中国产妇产后抑郁症状的相关性：一项前瞻性队列研究。
J Psychosom Res. 2023 May;168:111210. doi: 10.1016/j.jpsychores.2023.111210. Epub 2023 Mar 1.
2
Association of VDBP (rs4588 and rs7041) gene polymorphisms with susceptibility to postpartum depression in South Indian population: A cross-sectional study.VDBP（rs4588 和 rs7041）基因多态性与南印度人群产后抑郁症易感性的关联：一项横断面研究。
Psychiatry Res. 2022 Oct;316:114713. doi: 10.1016/j.psychres.2022.114713. Epub 2022 Jul 8.
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Genetic variants in the genes of the sex steroid hormone metabolism and depressive symptoms during and after pregnancy.
孕期及产后性激素代谢基因中的遗传变异与抑郁症状
Arch Gynecol Obstet. 2023 Jun;307(6):1763-1770. doi: 10.1007/s00404-022-06644-8. Epub 2022 Jun 10.
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Serotonin transporter: Recent progress of in silico ligand prediction methods and structural biology towards structure-guided in silico design of therapeutic agents.5-羟色胺转运体：基于结构的计算机辅助药物设计中计算配体预测方法和结构生物学的最新进展。
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Genetic Polymorphism of rs13306146 Affects Expression and Associated With Postpartum Depressive Symptoms in Chinese Women Who Received Cesarean Section.rs13306146的基因多态性影响剖宫产中国女性的表达并与产后抑郁症状相关。
Front Genet. 2021 Jul 7;12:675386. doi: 10.3389/fgene.2021.675386. eCollection 2021.
7
Correlations Between Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section.剖宫产中国产妇基因多态性与产后抑郁症状的相关性
Neuropsychiatr Dis Treat. 2020 Dec 24;16:3225-3238. doi: 10.2147/NDT.S278248. eCollection 2020.
8
Risk factors for postpartum depression: An evidence-based systematic review of systematic reviews and meta-analyses.产后抑郁症的风险因素：系统评价和荟萃分析的循证系统综述。
Asian J Psychiatr. 2020 Oct;53:102353. doi: 10.1016/j.ajp.2020.102353. Epub 2020 Aug 30.
9
The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women.中国女性剖宫产术后抑郁与犬尿氨酸途径和犬尿氨酸氨基转移酶等位基因的作用。
Brain Behav. 2020 Apr;10(4):e01566. doi: 10.1002/brb3.1566. Epub 2020 Feb 26.
10
Associations between maternal depression and mother and infant oxytocin receptor gene (OXTR_rs53576) polymorphisms.母亲抑郁与母婴催产素受体基因（OXTR_rs53576）多态性之间的关联。
Dev Psychobiol. 2020 May;62(4):496-504. doi: 10.1002/dev.21938. Epub 2019 Nov 21.