NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, P. R. China.
Department of Ultrasonography, Third Affiliated Hospital of Southern Medical University, Academy of Orthopedics, Guangzhou, Guangdong Province, 510515, P. R. China.
Small. 2024 Jun;20(25):e2311056. doi: 10.1002/smll.202311056. Epub 2024 Feb 20.
The poor efficiency and low immunogenicity of photodynamic therapy (PDT), and the immunosuppressive tumor microenvironment (ITM) lead to tumor recurrence and metastasis. In this work, TCPP-T-Zn@RSV nanosheets (TZR NSs) that co-assembled from the endoplasmic reticulum (ER)-targeting photosensitizer TCPP-T-Zn nanosheets (TZ NSs for short) and the autophagy promoting and indoleamine-(2, 3)-dioxygenase (IDO) inhibitor-like resveratrol (RSV) are fabricated to enhance antitumor PDT. TZR NSs exhibit improved therapeutic efficiency and amplified immunogenic cancer cell death (ICD) by ER targeting PDT and ER autophagy promotion. TZR NSs reversed the ITM with an increase of CD8+ T cells and reduce of immunosuppressive Foxp3 regulatory T cells, which effectively burst antitumor immunity thus clearing residual tumor cells. The ER-targeting TZR NSs developed in this paper presents a simple but valuable reference for high-efficiency tumor photodynamic immunotherapy.
光动力疗法（PDT）的效率低下和免疫原性低，以及免疫抑制性肿瘤微环境（ITM）导致肿瘤复发和转移。在这项工作中，共组装自内质网（ER）靶向光敏剂 TCPP-T-Zn 纳米片（简称 TZ NSs）和自噬促进和吲哚胺-(2,3)-双加氧酶（IDO）抑制剂样白藜芦醇（RSV）的 TCPP-T-Zn@RSV 纳米片（TZR NSs）被构建以增强抗肿瘤 PDT。TZR NSs 通过 ER 靶向 PDT 和 ER 自噬促进显示出改善的治疗效率和放大的免疫原性癌细胞死亡（ICD）。TZR NSs 逆转了 ITM，增加了 CD8+T 细胞，减少了免疫抑制性 Foxp3 调节性 T 细胞，从而有效爆发抗肿瘤免疫，清除残留的肿瘤细胞。本文中开发的 ER 靶向 TZR NSs 为高效肿瘤光动力免疫治疗提供了一个简单但有价值的参考。
