慢性基孔肯雅热（CCD）：临床见解、免疫发病机制和治疗观点。

Chronic chikungunya disease (CCD): clinical insights, immunopathogenesis and therapeutic perspectives.

机构信息

Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.

Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University, Gold Coast, QLD, Australia.

出版信息

QJM. 2024 Jul 1;117(7):489-494. doi: 10.1093/qjmed/hcae028.

DOI:10.1093/qjmed/hcae028

PMID:38377410

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11290245/

Abstract

Chikungunya virus, an arthropod-borne pathogen is recognized by the World Health Organization as a top priority Emerging Infectious Disease and is ranked fourth in public health needs according to the Coalition for Epidemic Preparedness Innovations. Despite its substantial impact, as evidenced by an annual estimate of 120 274 disability-adjusted life years, our understanding of the chronic aspects of chikungunya disease remains limited. This review focuses on chronic chikungunya disease, emphasizing its clinical manifestations, immunopathogenesis, therapeutic options and disease burden.

摘要

基孔肯雅热病毒是一种虫媒病原体，已被世界卫生组织确认为头号重点新兴传染病，根据流行病防范创新联盟的评估，基孔肯雅热在公共卫生需求方面排名第四。尽管基孔肯雅热的影响很大，据估计每年有 120 274 个残疾调整生命年，但其慢性方面的认识仍然有限。这篇综述重点介绍慢性基孔肯雅热，强调其临床表现、免疫发病机制、治疗选择和疾病负担。