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Genotypic Differences in Dengue Virus Neutralization Are Explained by a Single Amino Acid Mutation That Modulates Virus Breathing.登革病毒中和作用的基因型差异可由一个调节病毒呼吸的单氨基酸突变来解释。
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Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity.冷冻电镜结构阐明了具有治疗活性的抗基孔肯雅病毒人单克隆抗体的中和机制。
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Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus.具有抗基孔肯雅病毒治疗活性的广谱和超强效人单克隆抗体的分离与鉴定
Cell Host Microbe. 2015 Jul 8;18(1):86-95. doi: 10.1016/j.chom.2015.06.009.
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单克隆抗体作为抗基孔肯雅病毒的预防和治疗药物

Monoclonal Antibodies as Prophylactic and Therapeutic Agents Against Chikungunya Virus.

作者信息

Clayton April M

机构信息

Office of Global Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

出版信息

J Infect Dis. 2016 Dec 15;214(suppl 5):S506-S509. doi: 10.1093/infdis/jiw324.

DOI:10.1093/infdis/jiw324
PMID:27920182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5853615/
Abstract

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that is responsible for considerable epidemics worldwide and recently emerged in the Americas in 2013. CHIKV may cause long-lasting arthralgia after acute infection. With currently no licensed vaccines or antivirals, the design of effective therapies to prevent or treat CHIKV infection is of utmost importance and will be facilitated by increased understanding of the dynamics of chikungunya. In this article, monoclonal antibodies against CHIKV as viable prophylactic and therapeutic agents will be discussed.

摘要

基孔肯雅病毒（CHIKV）是一种由蚊子传播的甲病毒，在全球范围内引发了相当大规模的疫情，并且于2013年在美洲首次出现。CHIKV急性感染后可能导致持续时间较长的关节痛。由于目前尚无获批的疫苗或抗病毒药物，设计有效的预防或治疗CHIKV感染的疗法至关重要，而对基孔肯雅热动态的深入了解将有助于实现这一目标。在本文中，将讨论针对CHIKV的单克隆抗体作为可行的预防和治疗药物的情况。