Department of Neuroscience and Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA.
Diabetes. 2024 Mar 1;73(3):348-354. doi: 10.2337/dbi23-0002.
Adipose tissue innervation is critical for regulating metabolic and energy homeostasis. While the sympathetic efferent innervation of fat is well characterized, the role of sensory or afferent innervation remains less explored. This article reviews previous work on adipose innervation and recent advances in the study of sensory innervation of adipose tissues. We discuss key open questions, including the physiological implications of adipose afferents in homeostasis as well as potential cross talk with sympathetic neurons, the immune system, and hormonal pathways. We also outline the general technical challenges of studying dorsal root ganglia innervating fat, along with emerging technologies that may overcome these barriers. Finally, we highlight areas for further research to deepen our understanding of the afferent function of adipose innervation.
脂肪组织的神经支配对于调节代谢和能量平衡至关重要。虽然脂肪的交感传出神经支配已经得到很好的描述，但感觉或传入神经支配的作用仍较少被探索。本文综述了脂肪神经支配的先前工作以及脂肪组织感觉神经支配研究的最新进展。我们讨论了关键的开放性问题，包括脂肪传入在体内平衡中的生理学意义，以及与交感神经元、免疫系统和激素途径的潜在交叉对话。我们还概述了研究支配脂肪的背根神经节的一般技术挑战，以及可能克服这些障碍的新兴技术。最后，我们强调了进一步研究的领域，以加深我们对脂肪神经支配传入功能的理解。
