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原位单细胞分析揭示 SARS-CoV-2 感染过程中 IFI27 的定位情况。

In situ single-cell profiling sheds light on IFI27 localisation during SARS-CoV-2 infection.

机构信息

Division of Bioinformatics, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, 3010, Australia; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.

Division of Bioinformatics, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, 3010, Australia.

出版信息

EBioMedicine. 2024 Mar;101:105016. doi: 10.1016/j.ebiom.2024.105016. Epub 2024 Feb 19.

DOI:10.1016/j.ebiom.2024.105016
PMID:38377798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10884333/
Abstract

The utilization of single-cell resolved spatial transcriptomics to delineate immune responses during SARS-CoV-2 infection was able to identify M1 macrophages to have elevated expression of IFI27 in areas of infection.

摘要

单细胞分辨率空间转录组学在描绘 SARS-CoV-2 感染期间的免疫反应方面的应用能够鉴定 M1 巨噬细胞，在感染区域发现 IFI27 呈高表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efc4/10884333/0c6dda7855fa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efc4/10884333/0c6dda7855fa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efc4/10884333/0c6dda7855fa/gr1.jpg

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引用本文的文献

[1]
Spatial Omics in Clinical Research: A Comprehensive Review of Technologies and Guidelines for Applications.

Int J Mol Sci. 2025-4-22

[2]
Spatial-Omics Methods and Applications.

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