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小儿心脏移植术后手术技术对中、长期结果的影响。

Impact of the operative technique on mid- and long-term results following paediatric heart transplantation.

机构信息

Division for Pediatric and Congenital Heart Surgery, Ludwig Maximilian University, Munich, Germany.

Department of Cardiac Surgery, Ludwig Maximilian University, Munich, Germany.

出版信息

ESC Heart Fail. 2024 Jun;11(3):1602-1611. doi: 10.1002/ehf2.14718. Epub 2024 Feb 20.

Abstract

AIMS

The aim of this study is to evaluate and compare the impact of the bicaval technique versus the biatrial technique (by Lower and Shumway) in paediatric heart transplant patients. Only a few studies investigate this matter regarding the long-term outcome after paediatric heart transplantation. We compared the two surgical methods regarding survival, the necessity of pacemaker implantation.

METHODS AND RESULTS

All 134 patients (aged <18 years) - (group-1) biatrial (n = 84), versus (group-2) bicaval (n = 50), who underwent heart transplantation between October 1988 and December 2021, were analysed. Freedom from events were estimated using the Kaplan-Meier method. Potential differences were analysed using the log rank test and Cox proportional hazard models. Mean ± standard deviation: Bypass time (per minutes) was higher in the group 1 as compared with group 2 (P = 0.050). Survival was not significantly different (P = 0.604) in either groups. Eighteen patients required permanent pacemaker implantation in the group 1 and only one patient required it in the group 2 (P = 0.001).

CONCLUSIONS

Paediatric heart transplantation using bicaval technique results similar long-term survival compared with the biatrial technique. The incidence of atrial rhythm disorders was significantly higher in the biatrial group, requiring a higher frequency of pacemaker implantation in this group. As a results, the bicaval technique has replaced the biatrial technique in our centre.

摘要

目的

本研究旨在评估和比较双腔静脉技术与双心房技术(Lower 和 Shumway 法)在儿科心脏移植患者中的影响。只有少数研究调查了儿科心脏移植后长期结果方面的这个问题。我们比较了这两种手术方法在生存率、起搏器植入必要性方面的差异。

方法和结果

分析了 1988 年 10 月至 2021 年 12 月期间接受心脏移植的 134 名(年龄<18 岁)患者(组 1:双心房,n=84;组 2:双腔静脉,n=50)。使用 Kaplan-Meier 法估计无事件生存率。使用对数秩检验和 Cox 比例风险模型分析潜在差异。平均值±标准差:组 1 的体外循环时间(每分钟)明显高于组 2(P=0.050)。两组的生存率无显著差异(P=0.604)。组 1 中有 18 名患者需要永久性起搏器植入,而组 2 中只有 1 名患者需要起搏器植入(P=0.001)。

结论

与双心房技术相比,儿科心脏移植采用双腔静脉技术可获得相似的长期生存率。双心房组心房节律紊乱的发生率明显更高,需要更高频率的起搏器植入。因此,双腔静脉技术已在我们中心取代了双心房技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6f5/11098630/03a40603f564/EHF2-11-1602-g003.jpg

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