He Haolong, Zhou Jingying, Xu Xuan, Zhou Pinxi, Zhong Huan, Liu Mi
School of Acupuncture-Moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Key Laboratory of Acupuncture and Moxibustion Bioinformatics, Education Department of Hunan Province, Changsha, Hunan, China.
Front Physiol. 2024 Feb 6;15:1356317. doi: 10.3389/fphys.2024.1356317. eCollection 2024.
The intestine is the largest mechanosensitive organ in the human body whose epithelial cells, smooth muscle cells, neurons and enteroendocrine cells must sense and respond to various mechanical stimuli such as motility, distension, stretch and shear to regulate physiological processes including digestion, absorption, secretion, motility and immunity. Piezo channels are a newly discovered class of mechanosensitive ion channels consisting of two subtypes, Piezo1 and Piezo2. Piezo channels are widely expressed in the intestine and are involved in physiological and pathological processes. The present review summarizes the current research progress on the expression, function and regulation of Piezo channels in the intestine, with the aim of providing a reference for the future development of therapeutic strategies targeting Piezo channels.
肠道是人体最大的机械敏感器官，其上皮细胞、平滑肌细胞、神经元和肠内分泌细胞必须感知并响应各种机械刺激，如蠕动、扩张、拉伸和剪切力，以调节包括消化、吸收、分泌、蠕动和免疫在内的生理过程。Piezo通道是新发现的一类机械敏感离子通道，由Piezo1和Piezo2两个亚型组成。Piezo通道在肠道中广泛表达，并参与生理和病理过程。本综述总结了Piezo通道在肠道中的表达、功能和调节方面的当前研究进展，旨在为未来针对Piezo通道的治疗策略的发展提供参考。
