经皮椎体成形术与经皮后凸成形术治疗骨质疏松性椎体压缩骨折的比较：系统评价和荟萃分析的伞状评价方案。
Percutaneous vertebroplasty versus percutaneous kyphoplasty for osteoporotic vertebral compression fractures: an umbrella review protocol of systematic reviews and meta-analyses.
机构信息
Department of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
出版信息
BMJ Open. 2024 Feb 20;14(2):e075225. doi: 10.1136/bmjopen-2023-075225.
INTRODUCTION
Several systematic reviews and meta-analyses have confirmed that percutaneous vertebroplasty and percutaneous kyphoplasty showed safety and beneficial efficacy in patients with osteoporotic vertebral compression fractures. Whereas, there is wide variation among results, which are not conducive to the evaluation and use of clinicians. This study will investigate the efficacy and safety of percutaneous vertebroplasty and percutaneous kyphoplasty for the treatment of osteoporotic vertebral compression fractures, aiming to provide a more reliable evidence base for clinical practice in treating osteoporotic vertebral compression fractures.
METHODS AND ANALYSIS
We will retrieve the relevant articles using the five databases(PubMed, Scopus, EMBASE, Cochrane Library and Web of Science) from inception to March 2023 for systematic review and meta-analysis comparing the overall safety and efficacy of percutaneous vertebroplasty and percutaneous kyphoplasty in patients with osteoporotic vertebral compression fractures. Three reviewers will screen citation titles, abstracts and evaluate the full text of each relevant citation based on prespecified eligibility criteria. Any discrepancies in decisions between reviewers will be resolved through discussion. We will assess the methodological quality of the included studies according to A MeaSurement Tool to Assess systematic Reviews 2 checklist.
ETHICS AND DISSEMINATION
This umbrella review will inform clinical and policy decisions regarding the benefits and harms of percutaneous vertebroplasty versus percutaneous kyphoplasty for osteoporotic vertebral compression fractures. Neither primary data nor individual patient information will be collected, thus ethics approval is not required. Findings will be reported through a peer-reviewed publication, conference presentations and the popular press.
PROSPERO REGISTRATION NUMBER
CRD42021268141.
简介
多项系统评价和荟萃分析已经证实，经皮椎体成形术和经皮后凸成形术在骨质疏松性椎体压缩性骨折患者中具有安全性和有益疗效。然而，结果存在很大差异，不利于临床医生的评估和使用。本研究旨在为骨质疏松性椎体压缩性骨折的临床治疗提供更可靠的证据基础，将调查经皮椎体成形术和经皮后凸成形术治疗骨质疏松性椎体压缩性骨折的疗效和安全性。
方法和分析
我们将从建库至 2023 年 3 月，使用五个数据库（PubMed、Scopus、EMBASE、Cochrane Library 和 Web of Science）检索系统评价和荟萃分析相关文献，比较经皮椎体成形术和经皮后凸成形术治疗骨质疏松性椎体压缩性骨折患者的总体安全性和疗效。三名评审员将根据预设的纳入标准筛选引文标题、摘要和评估每个相关引文的全文。评审员之间的任何分歧将通过讨论解决。我们将根据 A MeaSurement Tool to Assess systematic Reviews 2 清单评估纳入研究的方法学质量。
伦理和传播
本综述将为经皮椎体成形术与经皮后凸成形术治疗骨质疏松性椎体压缩性骨折的获益和危害提供临床和政策决策信息。由于不会收集原始数据或个体患者信息，因此不需要伦理批准。研究结果将通过同行评议的出版物、会议演讲和大众媒体报告。
PROSPERO 注册号：CRD42021268141。
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