Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China.
Department of Radiation Oncology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China.
Sci Rep. 2024 Feb 21;14(1):4311. doi: 10.1038/s41598-024-54627-3.
Elevated serum ferritin (SF) levels have been associated with poor prognosis in various cancer types, but its impact on nasopharyngeal carcinoma (NPC) remains unclear. This retrospective study analyzed clinical data from 252 non-metastatic NPC patients admitted to Hainan General Hospital between January 2014 and May 2016. SF levels were measured using the chemiluminescence method. Patients were categorized into low, medium, and high-level SF groups based on tertile median SF levels. Survival outcomes were assessed using Kaplan-Meier analysis and Cox regression models. The overall survival rates of the entire patient cohort at 1, 3, 5, and 8 years were 95.2%, 85.7%, 76.2%, and 68.9% respectively. The high-level SF group (SF > 164.00 ng/mL) had significantly worse overall survival (83.1 vs 96.3 months, P = 0.023) and progression-free survival (77.8 vs 93.3 months, P = 0.019) compared to the low-level SF group. Univariate and multivariate analyses confirmed that high SF levels, along with T3/T4 staging and N3 staging, were independent risk factors for poor prognosis. In conclusion, high SF levels are associated with shorter overall survival and progression-free survival in NPC patients.
血清铁蛋白（SF）水平升高与多种癌症类型的预后不良有关，但它对鼻咽癌（NPC）的影响尚不清楚。本回顾性研究分析了 2014 年 1 月至 2016 年 5 月期间海南总医院收治的 252 例非转移性 NPC 患者的临床资料。采用化学发光法测量 SF 水平。根据三分位中位数 SF 水平将患者分为低、中、高水平 SF 组。采用 Kaplan-Meier 分析和 Cox 回归模型评估生存结局。整个患者队列的总生存率在 1、3、5 和 8 年时分别为 95.2%、85.7%、76.2%和 68.9%。高水平 SF 组（SF＞164.00ng/mL）的总生存率（83.1 与 96.3 个月，P＝0.023）和无进展生存率（77.8 与 93.3 个月，P＝0.019）明显低于低水平 SF 组。单因素和多因素分析证实，高水平 SF 水平以及 T3/T4 分期和 N3 分期是预后不良的独立危险因素。总之，高水平 SF 与 NPC 患者的总生存时间和无进展生存时间缩短相关。
