Reinilä A
Arch Pathol Lab Med. 1985 Mar;109(3):277-82.
Adult male rats were fed a high-fat cholesterol, thyroid-suppressive diet for three months, after which the structure of the muscular arteries (coronary and tarsal pedis) was examined by transmission electron microscopy. The plasma cholesterol concentration was elevated when the animals were killed and a distinct ultrastructural finding was the presence of necrotic cells in the media of both the coronary and the tarsal pedis arteries. Medial smooth muscle cells contained multivesicular membranous bodies, and membranous material accumulated in the intercellular space of the arterial media. It is proposed that the membrane changes and cellular death within muscular arteries may primarily be due to the increased membrane cholesterol concentration of smooth muscle cells during hypercholesterolemia. Dietary saturated fatty acids may have a contributing effect on smooth muscle cell injury in the hypercholesterolemic state.
成年雄性大鼠被喂食高脂、抑制甲状腺的饮食三个月，之后通过透射电子显微镜检查肌性动脉（冠状动脉和足背动脉）的结构。处死动物时血浆胆固醇浓度升高，一个明显的超微结构发现是冠状动脉和足背动脉中膜存在坏死细胞。中膜平滑肌细胞含有多囊泡膜性小体，膜性物质在动脉中膜的细胞间隙积聚。有人提出，肌性动脉内的膜变化和细胞死亡可能主要是由于高胆固醇血症期间平滑肌细胞膜胆固醇浓度增加所致。饮食中的饱和脂肪酸可能在高胆固醇血症状态下对平滑肌细胞损伤有促进作用。
