Hagmar B, Ryd W
Invasion Metastasis. 1985;5(1):31-41.
We have studied some cellular characteristics and the transplantability of a newly induced squamous cell carcinoma, Sq1-SC, in comparison with the ascites-transformed subline of the same tumor, Sq1-AA. We could demonstrate that the AA tumor differed from the SC tumor in the pattern of intravenously induced 'experimental metastases'. The SC tumor preferentially gave rise to extrapulmonary tumor colonies ('metastases'), while the AA tumor exclusively gave rise to lung colonies. Comparison with the ascites tumor growing in solid form subcutaneously (AS tumor) shows that the enzymatic treatment, which is necessary to bring solid tumors into viable and dissociated suspensions, can have a decisive influence on tumor cell lodgement in vessels and metastasis.
我们研究了一种新诱导的鳞状细胞癌Sq1-SC的一些细胞特征及其可移植性，并将其与同一肿瘤的腹水转化亚系Sq1-AA进行了比较。我们能够证明，AA肿瘤在静脉诱导的“实验性转移”模式上与SC肿瘤不同。SC肿瘤优先产生肺外肿瘤集落（“转移灶”），而AA肿瘤仅产生肺集落。与皮下生长的实体形式腹水肿瘤（AS肿瘤）比较表明，将实体肿瘤制成活的解离悬液所必需的酶处理，可对肿瘤细胞在血管中的着床和转移产生决定性影响。
