Freemasons Centre for Male Health and Wellbeing, The University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.
JBI Evid Synth. 2024 Jul 1;22(7):1393-1400. doi: 10.11124/JBIES-23-00195.
This review will determine whether various health interventions designed to reduce weight (lifestyle change, bariatric surgery, pharmacotherapy) in men with obesity are associated with improved fertility markers. The review will also establish whether the degree of weight loss achieved through these methods is associated with improvement.
Current preconception guidelines provide limited information for men with obesity. Small studies implementing lifestyle changes in men are associated with improvement in sperm quality, whereas bariatric surgery has not been associated with improvements in sperm quality. Determining the benefit of different interventions and the relationship to weight lost is necessary to optimize male fertility.
The population will be men younger than 50 years with overweight (BMI >25 kg/m 2 ) or obesity (BMI >30 kg/m 2 ). The exposure of interest will be an intervention undertaken to improve health or reduce weight, categorized as lifestyle change, bariatric surgery, or pharmacotherapy. Outcomes will include time to conception, fecundity rate, assisted reproduction outcomes, and semen quality measures. Secondary analysis will determine whether degree of weight loss achieved is associated with degree of improvement.
This review will follow the JBI methodology for systematic reviews of etiology and risk. Databases to be searched will include PubMed, Embase (Ovid), Cochrane Central Register of Controlled Trials, Web of Science Core Collection, and Scopus. Articles not published or translated into English will be excluded. Methodological quality will be assessed using the JBI critical appraisal tools. Data will be extracted using a tool developed by the reviewers. Statistical meta-analysis will be performed where possible to synthesize outcomes of similar methods.
PROSPERO CRD42022349665.
本综述旨在确定旨在减轻肥胖男性体重（生活方式改变、减重手术、药物治疗）的各种健康干预措施是否与改善生育标志物相关。本综述还将确定通过这些方法实现的减肥程度是否与改善相关。
目前的孕前指南为肥胖男性提供的信息有限。在男性中实施生活方式改变的小型研究与精子质量的改善相关，而减重手术与精子质量的改善无关。确定不同干预措施的益处及其与体重减轻的关系对于优化男性生育能力是必要的。
研究对象为年龄小于 50 岁、超重（BMI>25kg/m²）或肥胖（BMI>30kg/m²）的男性。感兴趣的暴露因素将是为改善健康或减轻体重而采取的干预措施，分为生活方式改变、减重手术或药物治疗。结局将包括受孕时间、受孕率、辅助生殖结局和精液质量指标。二次分析将确定实现的减肥程度与改善程度是否相关。
本综述将遵循 JBI 病因和风险系统评价方法学。将搜索的数据库包括 PubMed、Embase（Ovid）、Cochrane 中心对照试验注册库、Web of Science 核心合集和 Scopus。未发表或未翻译成英文的文章将被排除。使用 JBI 批判性评估工具评估方法学质量。使用审查员开发的工具提取数据。如有可能，将进行统计荟萃分析以综合类似方法的结局。
PROSPERO CRD42022349665。
