Department of Rheumatology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Clin Exp Med. 2024 Feb 22;24(1):41. doi: 10.1007/s10238-024-01303-5.
The spotlight in recent years has increasingly focused on inducible regulatory T cells 35 (iTr35), a novel subpopulation of regulatory T cells characterized by phenotypic stability, heightened reactivity, and potent immunosuppressive function through the production of IL-35. Despite being in the exploratory phase, research on iTr35 has garnered significant interest. In this review, we aim to consolidate our understanding of the biological characteristics and immunomodulatory mechanisms of iTr35, offering fresh perspectives that may pave the way for its potential applications in disease diagnosis and treatment.
近年来，研究的焦点越来越集中在诱导性调节性 T 细胞 35（iTr35）上，这是一种新型的调节性 T 细胞亚群，其特征是表型稳定、反应性增强，并通过产生 IL-35 发挥强大的免疫抑制功能。尽管仍处于探索阶段，但 iTr35 的研究引起了广泛关注。在这篇综述中，我们旨在整合对 iTr35 的生物学特性和免疫调节机制的理解，提供新的观点，为其在疾病诊断和治疗中的潜在应用铺平道路。
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