Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China.
School of Nursing, Anhui Medical University, Hefei, 230032, Anhui, China.
Sci Rep. 2024 Feb 22;14(1):4384. doi: 10.1038/s41598-024-54496-w.
To investigate the frequency of monocytic myeloid-derived suppressor cells (M-MDSCs) in type 2 diabetes mellitus (T2DM) patients and explore the potential associations between M-MDSCs, glycemic control, and the occurrence of infections and tumor. 102 healthy and 77 T2DM individuals were enrolled. We assessed the M-MDSCs frequency, levels of fasting plasma glucose (FPG), haemoglobin A1c (HbA1c), and other relevant indicators. Each patient underwent a follow-up of at least 6 months after M-MDSCs detection. The M-MDSCs frequency was significantly higher in patients with poor glycemic control (PGC) compared to the healthy population (P < 0.001), whereas there was no significant difference between patients with good glycemic control and the healthy (P > 0.05). There was a positive correlation between the M-MDSCs frequency and FPG, HbA1c (R = 0.517 and 0.315, P < 0.001, respectively). T2DM patients with abnormally increased M-MDSCs have a higher incidence of infection and tumor (48.57% and 11.43% respectively). Our results shed new light on the pathogenesis of T2DM, help to understand why T2DM patients are susceptible to infection and tumor and providing novel insights for future prevention and treatment of T2DM.
探讨 2 型糖尿病（T2DM）患者中单核细胞来源的髓系抑制细胞（M-MDSC）的频率，并探讨 M-MDSC 与血糖控制、感染和肿瘤发生之间的潜在关联。方法：纳入 102 名健康个体和 77 名 T2DM 个体。评估 M-MDSC 频率、空腹血糖（FPG）、糖化血红蛋白（HbA1c）水平和其他相关指标。每位患者在检测 M-MDSC 后至少进行了 6 个月的随访。结果：与健康人群相比，血糖控制不佳（PGC）患者的 M-MDSC 频率显著升高（P<0.001），而血糖控制良好患者与健康人群之间无显著差异（P>0.05）。M-MDSC 频率与 FPG、HbA1c 呈正相关（R=0.517 和 0.315，P<0.001）。M-MDSC 异常升高的 T2DM 患者感染和肿瘤的发生率较高（分别为 48.57%和 11.43%）。结论：本研究结果为 T2DM 的发病机制提供了新的视角，有助于理解为什么 T2DM 患者易感染和发生肿瘤，并为 T2DM 的未来预防和治疗提供了新的思路。
