基于血浆纤维蛋白原和血小板-淋巴细胞比值的联合评分作为食管鳞癌的预后生物标志物。
Combined score based on plasma fibrinogen and platelet-lymphocyte ratio as a prognostic biomarker in esophageal squamous cell carcinoma.
机构信息
Department of GI Medical Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Key Laboratory of Cancer Prevention and Therapy, Huanhuxi Road, Tiyuanbei, Hexi District, 300060, Tianjin, China.
Department of Surgical Oncology and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
出版信息
BMC Cancer. 2024 Feb 22;24(1):249. doi: 10.1186/s12885-024-11968-6.
BACKGROUND
Increasing evidence has showed that inflammatory biomarkers, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and fibrinogen can be used as predictors in the prognosis of esophageal squamous cell carcinoma (ESCC). The aim of this study was to explore prognostic value of these biomarkers and evaluate the clinicopathological and prognostic significance of combined score based on plasma fibrinogen and platelet-lymphocyte ratio (F-PLR score).
METHODS
A total of 506 patients with ESCC were enrolled in this study. Harrell's concordance index (c-index) was used to determine the optimal cut-off values of these markers and evaluate their prognostic significance. The relationship between factors with survival rates (including overall survival [OS] and disease-free survival [DFS]) was explored by Kaplan-Meier curve, univariate analysis and multivariate cox hazard analysis.
RESULTS
Our result indicated that high F-PLR score was significantly associated with longer tumor length and deeper depth of tumor invasion (p < 0.01). The result of Cox multivariable analysis showed that F-PLR score was an independent prognostic factor for OS (p = 0.002) and DFS (p = 0.003). In addition, F-PLR score presented the greater c-index values for OS and DFS compared with NLR, PLR and fibrinogen level. Our result also showed that the c-index values for OS and DFS were both greater in TNM + F-PLR than those in TNM stage alone.
CONCLUSIONS
In conclusion, F-PLR score is a predictive biomarker for prognosis in patients with ESCC.
背景
越来越多的证据表明，炎症生物标志物，包括中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和纤维蛋白原，可以作为食管鳞癌（ESCC）预后的预测指标。本研究旨在探讨这些生物标志物的预后价值，并评估基于血浆纤维蛋白原和血小板-淋巴细胞比值（F-PLR 评分）的联合评分的临床病理和预后意义。
方法
本研究共纳入 506 例 ESCC 患者。采用 Harrell 一致性指数（c-index）确定这些标志物的最佳截断值，并评估其预后意义。通过 Kaplan-Meier 曲线、单因素分析和多因素 Cox 风险分析探讨与生存率（包括总生存率[OS]和无病生存率[DFS]）相关的因素之间的关系。
结果
结果表明，高 F-PLR 评分与肿瘤长度较长和肿瘤侵袭深度较深显著相关（p<0.01）。Cox 多因素分析结果表明，F-PLR 评分是 OS（p=0.002）和 DFS（p=0.003）的独立预后因素。此外，F-PLR 评分在 OS 和 DFS 方面的 C-index 值均高于 NLR、PLR 和纤维蛋白原水平。结果还表明，在 TNM+F-PLR 中，OS 和 DFS 的 C-index 值均大于 TNM 分期。
结论
总之，F-PLR 评分是 ESCC 患者预后的预测生物标志物。
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