甲状腺嗜酸细胞癌：20 年患者队列的结论。

Oncocytic carcinoma of the thyroid: Conclusions from a 20-year patient cohort.

机构信息

Department of Otolaryngology - Head & Neck Surgery, University of Virginia, Charlottesville, Virginia, USA.

School of Medicine, University of Virginia, Charlottesville, Virginia, USA.

出版信息

Head Neck. 2024 Aug;46(8):2042-2047. doi: 10.1002/hed.27700. Epub 2024 Feb 23.

DOI:10.1002/hed.27700

PMID:38390640

Abstract

BACKGROUND

Oncocytic carcinoma (OCA) was recently reclassified as a distinct differentiated thyroid carcinoma (DTC). Given its rarity, OCA studies are limited. This study describes the characteristics of OCA in a 20-year cohort.

METHODS

Retrospective analysis of patients with OCA at a single tertiary care hospital from 2000 to 2021.

RESULTS

Fifty-one OCA patients (22M:29F) were identified. The mean age at diagnosis was 60.3 years; 90% presented as palpable mass; 24% had a family history of thyroid cancer. None had vocal fold paresis. On ultrasound, most tumors were solid and hypoechoic. FNA (n = 14) showed Bethesda-4 lesions in 93%. All were treated surgically. Histologically, 63% demonstrated angioinvasion, 35% had lymphovascular invasion, and 15% had extrathyroidal extension. Radioactive iodine was used as adjunct therapy in 77%.

CONCLUSION

OCA has distinct features that distinguish it from other DTCs, and additional focused studies will help clarify the aggressive nature, treatment options, and prognosis of the disease.

摘要

背景

嗜酸细胞癌（OCA）最近被重新归类为一种独特的分化型甲状腺癌（DTC）。鉴于其罕见性，对 OCA 的研究有限。本研究描述了 20 年队列中 OCA 的特征。

方法

对 2000 年至 2021 年在一家三级保健医院的 OCA 患者进行回顾性分析。

结果

共确定了 51 例 OCA 患者（22 例男性：29 例女性）。诊断时的平均年龄为 60.3 岁；90%表现为可触及的肿块；24%有甲状腺癌家族史。无声带麻痹。在超声检查中，大多数肿瘤为实性和低回声。FNA（n=14）显示 93%的病变为 Bethesda-4 级。所有患者均接受手术治疗。组织学上，63%显示血管侵犯，35%有血管淋巴管侵犯，15%有甲状腺外侵犯。77%的患者使用放射性碘作为辅助治疗。