Egerton J R, Eary C H, Suhayda D
Am J Vet Res. 1985 May;46(5):1057-9.
Dose-titration trials of ivermectin were conducted on pups with dual experimental infections of 4th-stage larvae or adult Ancylostoma caninum and Uncinaria stenocephala. Ivermectin was administered orally or subcutaneously at dosages of 0.006, 0.012, or 0.024 mg/kg of body weight. Maximal or near maximal (greater than or equal to 96% to 100%) anthelmintic effect was observed for both stages of development for each hookworm species by either route of administration at a dosage of 0.024 mg/kg. Responses for all of the aforementioned categories were linearly related to increasing log dosage of ivermectin, with common slopes (regression coefficients). Regression analysis also provided estimates of the minimal dosages required to produce maximal reduction in worm burden for each stage, species, and route of administration. The estimated ivermectin dosages for maximal efficacy ranged from a low of 0.014 mg/kg for adult A caninum by oral treatment to 0.044 mg/kg for 4th-stage larvae of U stenocephala by oral treatment.
对感染了第四期幼虫或成虫犬钩虫和窄头钩口线虫双重感染的幼犬进行了伊维菌素剂量滴定试验。伊维菌素通过口服或皮下注射给药，剂量为0.006、0.012或0.024毫克/千克体重。对于每种钩虫物种的两个发育阶段，通过任何一种给药途径，在剂量为0.024毫克/千克时均观察到最大或接近最大（大于或等于96%至100%）的驱虫效果。上述所有类别的反应与伊维菌素对数剂量的增加呈线性相关，具有共同的斜率（回归系数）。回归分析还提供了每个阶段、物种和给药途径产生最大蠕虫负荷减少所需的最小剂量估计值。估计产生最大疗效的伊维菌素剂量范围从口服治疗成年犬钩虫的低剂量0.014毫克/千克到口服治疗窄头钩口线虫第四期幼虫的0.044毫克/千克。
