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β-内酰胺抗生素的新型增效剂。从紫色杆菌中分离出SQ28,504和SQ28,546。

Novel potentiators of beta-lactam antibiotics. Isolation of SQ28,504 and SQ28,546 from Chromobacterium violaceum.

作者信息

Cooper R, Wells J S, Sykes R B

出版信息

J Antibiot (Tokyo). 1985 Apr;38(4):449-54.

PMID:3839229
Abstract

Two novel compounds, SQ28,504 and SQ28,546 are produced by Chromobacterium violaceum. These compounds enhance the antibacterial activity of beta-lactam antibiotics against Gram-negative organisms. Both SQ28,504 and SQ28,546 induce morphological changes in the presence of beta-lactam antibiotics. Only SQ28,546 has weak antimicrobial activity against several Gram-negative organisms.

摘要

两种新型化合物，即紫色杆菌素（SQ28,504）和SQ28,546，由紫色色杆菌产生。这些化合物可增强β-内酰胺类抗生素对革兰氏阴性菌的抗菌活性。在存在β-内酰胺类抗生素的情况下，SQ28,504和SQ28,546都会诱导形态变化。只有SQ28,546对几种革兰氏阴性菌具有微弱的抗菌活性。

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